Developing Imaging And plasMa biOmarkers iN Describing Heart Failure With Preserved Ejection Fraction (DIAMONDHFpEF) — DIAMONDHFpEF  

Healthy Controls Group - Age and Sex-matched Clinical Trial

Official title: Prospective, Observational, Single-centre, Cohort Study Aimed at Developing Imaging and Plasma Biomarkers in Heart Failure With Preserved Ejection Fraction

Status Completed

Clinical Trial Summary

The investigators wish to test a hypothesis that patients with HFpEF have different characteristics on echo, cardiac MRI and plasma protein & chemical profiles compared to HFrEF and healthy volunteers.

Clinical Trial Description

Large scale prospective studies incorporating cardiac MRI, echocardiography and plasma sampling are currently lacking in HFpEF. The main aims of our study are to:

1. better phenotype and characterise HFpEF (also comparing with HFrEF and age- and sex- matched healthy controls)

2. provide mechanistic insights into pathophysiology

3. describe potential biomarkers and their relation to relevant clinical outcomes (exercise capacity, heart failure quality of life and prognosis) ;

Related Conditions & MeSH terms

• Healthy Controls Group - Age and Sex-matched
• Heart Failure
• Patients With Heart Failure and Preserved Ejection Fraction - HFpEF
• Patients With Heart Failure With Reduced Ejection Fraction - HFrEF

• NCT number: NCT03050593
• Study type: Observational
• Source: University of Leicester
• Status: Completed
• Phase: N/A
• Start date: February 2013
• Completion date: May 2015