Effect of Beet-root Juice and PBM Treatments on Muscle Fatigue

Healthy Aging Clinical Trial

Official title:

Application of Beet-root Juice Supplementation and Photobiomodulation Treatment on Forearm Muscle Fatigue in Older Adults

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05596474
• Other study ID #: IRB00024675
• Status: Recruiting
• Phase: N/A
• Start date: September 9, 2022
• Est. completion date: August 31, 2024

Study information

• Verified date: March 2024
• Source: Wake Forest University
• Contact: Andrew D Wells, Ph.D.
• Phone: (336) 758-5837
• Email: wellsa[@]wfu.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of this randomized counterbalanced repeated measures study is to test beet-root juice supplementation and red light therapy augment forearm muscle endurance in apparently healthy older adults over 65 years of age. The main questions seek to answer the following question:

Does beet-root juice supplementation improve forearm muscle endurance compared to a placebo supplement?

Does red light therapy improve forearm muscle endurance compared to a sham light exposure?

Does beet-root juice supplementation in combination with red light therapy improve forearm muscle endurance compared to a placebo-sham light control?

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 10
• Est. completion date: August 31, 2024
• Est. primary completion date: August 31, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 65 Years and older

Eligibility

Inclusion Criteria:

• Self-reports performing at least 30 minutes of light to moderate intensity physical activity 3 times per week for the last three months

Exclusion Criteria:

• Currently smoke

• Have smoked within the last 6 months

• Are taking taking supplements known to increase blood nitrate levels

• Have a known kidney disease

• Have a known liver disease

• Have a known thyroid condition

• Have a known gastritis condition

• Are taking medications that are known to cause complications with nitrate supplementation

• Have known or reported joint pain within the dominant hand

Related Conditions & MeSH terms

• Fatigue
• Health Care Utilization
• Healthy Aging

Intervention

Dietary Supplement:
• Beet-root juice
Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a 400mg nitrate once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third 400mg dose of nitrates at least 150 minutes before forearm endurance testing.

Radiation:
• red-light therapy
Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to 660nm wave length light for 10-minutes.

Dietary Supplement:
• Placebo
Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a nitrate depleted placebo once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third dose of the nitrate depleted placebo at least 150 minutes before forearm endurance testing.

Radiation:
• sham light
Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to sham light for 10-minutes.

Locations

Country	Name	City	State
United States	Wake Forest Univesity	Winston-Salem	North Carolina

Sponsors (1)

Lead Sponsor	Collaborator
Wake Forest University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Total forearm work performed	Work is the product of the number of times the forearm is activated multiplied by the amount of force produced by the forearm in kilograms.	During the forearm exercise fatigue protocol lasting up to 45 minutes
Secondary	Forearm endurance	The duration of time the participant takes to complete the forearm fatigue protocol	During the forearm exercise fatigue protocol lasting up to 45 minutes
Secondary	Intermuscular coordination	Surface electromyography measurements of muscle activity	During the forearm exercise fatigue protocol lasting up to 45 minutes