Head and Neck Squamous Cell Carcinoma Clinical Trial
Official title:
A Clinical Trial to Evaluate the Efficacy and Safety of CX1106 in Patients With Metastatic/Recurrent Head and Neck Squamous Cell Carcinoma After Failure of or Unfit for Platinum-containing Therapy
CX1106 is a novel inhibitor of thymidylate synthase (TS) developed as a potential antitumor
agent by virtue of the rate limiting role of TS in the biosynthesis of thymidine. CX1106
differs from other TS inhibitors such as pemetrexed, raltitrexed, CB3717, and fluorouracil in
that it does not require active transport for uptake into cells. CX1106 also lacks a
glutamate moiety and thus does not require polyglutamation for antitumor activity. More than
1000 patients with various malignancies have been treated with CX1106 to date in previous
various clinical trials.
The investigators suggest a study of CX1106 in patients with recurrent or metastatic HNSCC
who are resistant or ineligible/intolerant to platinum-based chemotherapy. The aim of current
trial is to evaluate the antitumor efficacy and safety profile of CX1106.
n/a
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