Head and Neck Neoplasms Clinical Trial
— CHIRPOfficial title:
Collection of Head Images During Radiotherapy (CHIRP)
Verified date | June 2024 |
Source | University of Sydney |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The primary objective of this observational study is to quantify the translation, rotation, and deformation of patient head positions of head and neck cancer patients over the course of a radiation therapy treatment for head and neck cancer. This objective will be achieved by comparing X-ray images collected during each treatment session with those obtained from the planning CT scan. Secondary objectives include (1) the use of the collected X-ray images to develop realistic artificial X-ray images where patient movement can be simulated and (2) to determine whether motion can be detected from individual X-ray images acquired during radiation therapy treatment.
Status | Active, not recruiting |
Enrollment | 32 |
Est. completion date | December 31, 2024 |
Est. primary completion date | December 31, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - A diagnosis of head and neck cancer (any stage) - Age 18 years or greater - Receiving radiation therapy to the head and neck with a thermoplastic immobilisation mask - An ECOG score in the range of 0 to 2 - Any other prior or concurrent therapy allowed Exclusion Criteria: - People with cognitive impairment which would preclude them from providing informed consent - People who are unable to speak and read English and for whom obtaining consent would be difficult. |
Country | Name | City | State |
---|---|---|---|
Australia | Blacktown Hospital | Blacktown | New South Wales |
Lead Sponsor | Collaborator |
---|---|
University of Sydney | Western Sydney Local Health District |
Australia,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Translational head motion between different radiation therapy treatment sessions | Translation error (mm) | 8 weeks | |
Primary | Rotational head motion between different radiation therapy treatment sessions | Rotation error (degree) | 8 weeks | |
Primary | Head deformation between different radiation therapy treatment sessions | Deformation error (mm) | 8 weeks | |
Secondary | Difference in structural similarity (SSIM) indexes between artificial and real X-rays | Image quality metric: Structural Similarity (SSIM) index. | 8 weeks | |
Secondary | Difference in mean absolute error between artificial and real X-rays | Image quality metric: Mean Absolute Error. | 8 weeks |
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