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The Impact of Pentoxifylline and Vitamin E on Radiotherapy-induced Toxicity in Head & Neck Cancer Patients

Head and Neck Neoplasms Clinical Trial

Official title:
The Impact of Pentoxifylline and Vitamin E on The Incidence and Severity of Radiotherapy- Induced Oral Mucositis and Dysphagia in Patients With Head and Neck Cancer

Clinical Trial Summary

The purpose of this study is to determine whether pentoxifylline and vitamin E are effective in prevention of radiotherapy- induced toxicity in head and neck cancer patients treated with concurrent chemoradiotherapy.

Clinical Trial Description

This is a randomized controlled prospective study of pentoxifylline and vitamin E given on daily basis throughout the period of concurrent chemoradiotherapy to patients with carcinoma of the head and neck. All patients will be followed up to 90 days since the first day of treatment. The incidence and severity of adverse events will be assessed according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 4. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02397486
Study type Interventional
Source Ain Shams University
Contact
Status Completed
Phase Phase 2
Start date May 2, 2015
Completion date June 30, 2018
View Details
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