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Clinical Trial Summary

The purpose of this study is to identify and confirm new blood and tissue markers for prognosis and tumor hypoxia. Tumor hypoxia, or the condition of low oxygen in the tumor, has been shown to increase the risk of tumor spread and enhance tumor resistance to the standard treatment of radiation and chemotherapy in head and neck and lung cancers. We have recently identified several proteins or markers in the blood and in tumors (including osteopontin, lysyl oxidase, macrophage inhibiting factor and proteomic technology) in the laboratory that may be able to identify tumors with low oxygen levels or more aggressive behaving tumors.


Clinical Trial Description

The endpoints of the study are 1. To validate the prognostic significance of OPN in H&N and lung cancer patients and to monitor its level during active therapy and follow up for cancer surveillance. 2. To identify a gene and protein signature for hypoxia in H&N and lung cancer patients. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT00568490
Study type Observational
Source Stanford University
Contact Eyiwunmi Laseinde
Email Rad-onc-ccto@lists.stanford.edu
Status Recruiting
Phase
Start date September 1, 1998
Completion date April 30, 2025

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