HBV Infection Clinical Trial
Official title:
Hepatitis D Virus Infection Among Hepatitis B Virus Surface Antigen Positive Individuals in Upper Egypt: Prevalence and Clinical Features
Globally, about 248 million people are chronic HBV surface antigen carriers, and about 5% of
them also had hepatitis delta virus (HDV) infection as well. The prevalence of HBsAg in Egypt
is intermediate (2-7%) .
Hepatitis D virus (HDV) is an incomplete RNA virus that needs hepatitis B surface antigen
(HBsAg) to help its replication. HDV is considered a subviral particle because it depends on
HBV for its propagation. Combined HDV- HBV infection produces more severe liver affection
than HBV alone.
HDV infection leads to both of acute and chronic liver illnesses. Acute HDV infection can
occur at the same time with acute HBV infection (coinfection) or can be superimposed on the
top of chronic HBV infection. About 20% to 30% of coinfections of HDV and HBV in humans
develop fatal fulminant hepatitis versus 2% of patients with acute hepatitis B
mono-infection. Worldwide, Hepatitis D virus (HDV) infection present in more than 15 million
people and it is endemic in the Middle East . In Upper Egypt, data about the prevalence,
clinical, laboratory and virological characters of Hepatitis D virus-infected patients is
rare.
This study aims were:
1. To estimate the prevalence of hepatitis D virus infection among HBsAg positive
individuals.
2. To determine the clinical, laboratory and virological characters of HDV infected
patients.
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