Integrated Multiomics and Multilevel Characterization of Haematological Disorders and Malignancies — INTHEMA  

Haematological Malignancy Clinical Trial

Official title: Integrated Multiomics and Multilevel Characterization of Haematological Disorders and Malignancies

Status Recruiting

Clinical Trial Summary

Exploratory multicenter, non-interventional, translational, retrospective and prospective study. All patients with a diagnosis of hematologic disorder or malignancy for whom biological samples and clinical data are available may be included in this study, after obtaining informed consent

Clinical Trial Description

Hematological malignancies account for approximately 9.5% of newly diagnosed cancers every year and their incidence shows an exponential rise after the age of 40. Since life expectancy is dramatically and continuously increasing worldwide, hematological diseases promise to become a substantial burden for the health care systems of the European society. The management of hematological malignancies is further complicated by the high level of disease heterogeneity in terms of pathogenic and molecular mechanisms. Due to the high level of heterogeneity in terms of cytogenetic, genetic, epigenetic, transcriptional, post-transcriptional and metabolic alterations, an accurate molecular classification of hematological diseases is needed to improve clinical outcomes and patients' management. This is an exploratory multicenter, non-interventional, translational, retrospective and prospective study. All patients with a diagnosis of hematologic disorder or malignancy for whom biological samples and clinical data are available may be included in this study, after obtaining informed consent. The primary objective is to improve our knowledge of the pathogenic mechanisms driving malignant disorders and transformation. The secondary objectives aim to improve diagnosis and stratification of onco-hematological patients and study drug response at preclinical level. After signing informed consent to the study, each patient will donate part of the samples (peripheral blood, bone marrow, biopsies) collected as per routine clinical practice for the management of their disease. ;

Related Conditions & MeSH terms

• Haematologic Disease
• Haematological Malignancy
• Hematologic Diseases
• Hematologic Neoplasms
• Neoplasms

• NCT number: NCT04298892
• Study type: Observational [Patient Registry]
• Source: Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori
• Contact: Oriana Nanni, Dr
• Phone: +39 0543 739100
• Email: oriana.nanni@irst.emr.it
• Status: Recruiting
• Start date: January 7, 2020
• Completion date: February 2025