Colorectal Cancer Clinical Trial
Official title:
Volatile Marker Testing for Digestive Cancer and Precancerous Lesion Detection, Evaluation of Confounding Factors
The study is aimed to determine the potential of volatile marker testing for identification
of gastrointestinal cancers (in particular - colorectal and gastric cancers), the related
precancerous lesions in the stomach and colon.
The study will be addressing the role of confounding factors, including lifestyle factors,
diet, smoking as well as addressing the potential role of microbiota in the composition of
exhaled volatile markers.
Patients with established disease (cancer, precancerous lesions) as well as patients
investigated for the lesions and having been documented lack of the lesions will be enrolled
to the study at clinical sites in Europe (Latvia, Lithuania). In addition, group of persons
from general population at average risk for developing the target disease will be also
enrolled.
Testing of volatile markers will be conducted by one of two methods: 1) gas chromatography
coupled to mass spectroscopy (GS-MS) and 2) nanosensor technology.
Volunteers (including patients with established disease) will be enrolled prior the removal
of the target lesion (e.g. surgery for cancer or polypectomy in the case of a polyp).
The study will be conducted by utilizing the experience of institutions in the European Union
and Israel.
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