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Graft Loss clinical trials

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NCT ID: NCT04733131 Active, not recruiting - Immunosuppression Clinical Trials

Long-term Outcomes After Conversion to Belatacept

Start date: January 1, 2004
Study type: Observational

belatacept is a selective T-cell co-stimulation blocker that was approved by Food and Drug Administration (FDA) in 2011 for the prophylaxis of graft rejection in adult kidney transplant recipients. This treatment is indicated as an alternative to Calcineurin Inhibitors (CNIs) for prophylaxis of graft rejection in de novo renal transplant recipients. Long term efficacy and safety outcomes of a kidney transplant population converted to a belatacept regimen after transplant have not been yet reported.

NCT ID: NCT04367610 Completed - Clinical trials for Kidney Transplant Rejection

Effects of A Standardized Treatment Approach on Kidney Transplant Recipients With Antibody-Mediated Rejection

Start date: September 1, 2019
Study type: Observational

Antibody-mediated rejection (ABMR) is one of the leading causes of graft loss in kidney transplant recipients (KTRs). Although it is a well characterized entity, there is limited data regarding effective treatment options for preserving graft functions. Moreover, results from different studies have been contradictory. Therefore, we conducted a study using our registry data to evaluate the effects of a standardized treatment approach consisting of therapeutic plasma exchange (regular plasmapheresis, double filtration plasmapheresis or immunoadsorption), intravenous immunoglobulin and rituximab on KTRs with acute or chronic ABMR.

NCT ID: NCT03412838 Completed - Graft Loss Clinical Trials

Factors Influencing Bone Block Allograft Resorption

Start date: January 2011
Phase: N/A
Study type: Interventional

A main drawback of bone block graft surgery is the resorption occurring in early stages of healing. The aim of this work was investigate different factors associated with graft resorption in allogeneic bone block graft surgery.

NCT ID: NCT03393598 Recruiting - Graft Loss Clinical Trials

Recipient Site Pre-conditioning in Fat Grafting

Start date: January 8, 2018
Phase: N/A
Study type: Interventional

This study aims to investigate the preparation of the recipient site prior to autologous fat grafting (AFG) using different methods.

NCT ID: NCT03197103 Active, not recruiting - Graft Loss Clinical Trials

The Impact of N-Acetylcysteine on Volumetric Retention of Autologous Fat Graft for Breast Asymmetry Correction

Start date: July 4, 2017
Phase: Phase 4
Study type: Interventional

The aim of this study is to assess the effect of new tumescent solution for liposuction containing N-Acetylcysteine (Pietruski solution) on the autologous fat graft volumetric retention used for healthy women breast asymmetry correction by means of lipofilling.

NCT ID: NCT02788292 Not yet recruiting - Graft Loss Clinical Trials

Effect of N-Acetylcysteine on Autologous Fat Graft Survival

Start date: July 2016
Phase: Phase 4
Study type: Interventional

A single-centre triple-blind study looking at the addition of NAC to tumescent solution for liposuction and fat grafting in healthy patient volunteers already undergoing bilateral breast reduction. Three-dimensional reconstructions and volumetric analysis will be performed based on CT scans at 0, 1 and 3 months and then histological analysis will be performed after fat graft explantation at 3 months to determine fat graft vascularity and quality.

NCT ID: NCT02387151 Completed - Rejection Clinical Trials

Allogeneic Mesenchymal Stromal Cell Therapy in Renal Transplant Recipients

Start date: March 2015
Phase: Phase 1
Study type: Interventional

This study will test whether selected allogeneic bone marrow derived MSCs are safe by assessing the composite end point Biopsy Proven Acute Rejection (BPAR)/ graft loss at 12 months.

NCT ID: NCT01301118 Suspended - Infection Clinical Trials

Graft Take and Microbiology in Burns

Start date: October 2010
Phase: N/A
Study type: Observational

SPLIT-THICKNESS SKIN GRAFT TAKE AND MICROBIOLOGICAL EVALUATION IN BURNED PATIENTS INTRODUCTION: Infection is cause of increased morbidity and mortality in burn patients, and its control is a major challenge also for skin graft integration. Wound and soft tissue infection rates are higher than microbiological diagnosis rates. PURPOSE: To evaluate partial skin graft integration in relation to microbiological analysis of wounds in burn patients. METHODS: This project will be a transversal, prospective, analytical, controlled study in humans, conducted in a single center, at Burn Care Unit of Department of Plastic Surgery at Federal University of São Paulo from October, 2010 to October, 2011. Data will be collected to characterize demographic and clinical aspects. Data analysis will be performed using Student's t-test and Friedman analysis of variance.