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Glucose Metabolism Disorders clinical trials

View clinical trials related to Glucose Metabolism Disorders.

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NCT ID: NCT04369833 Completed - Diabetes Mellitus Clinical Trials

Development of Continuous Glucose Monitoring System Cohort for Personalized Diabetes Prevention and Management Platform

Start date: May 11, 2020
Phase:
Study type: Observational [Patient Registry]

The purpose of this study is to collect a variety of clinical data and blood glucose changes using a continuous glucose monitoring device for high-risk diabetes patients (prediabetes) in order to develop a personalized diabetes prevention and management platform based on artificial intelligence model using mathematical analysis.

NCT ID: NCT04346836 Completed - Obesity Clinical Trials

Low-intensity Exercise in Metabolic Syndrome

Start date: May 6, 2018
Phase: N/A
Study type: Interventional

People with metabolic syndrome (MetS) are characterized by a lower quality of life in terms of reduced vital activity, emotional state, and social functioning. Therefore, the investigator's aim was to determine the impact of low-intensity exercise and psychoeducation on depression symptoms and self-perceived stress in women with MetS.

NCT ID: NCT04125602 Completed - Clinical trials for Postprandial Hyperglycemia

Westlake N-of-1 Trials for Macronutrient Intake

WE-MACNUTR
Start date: October 20, 2019
Phase: N/A
Study type: Interventional

This is a dietary intervention study in students and staff of Westlake University, which is designed to provide evidence in support of N-of-1 methods as an approach to advance personalized nutrition. The primary aim is using a series of N-of-1 trials to determine the impacts of a high fat, low carbohydrate diet (HF-LC) on glucose metabolism and gut microbiota in subjects versus a low fat, high carbohydrate diet (LF-HC) at both the individual and group level.

NCT ID: NCT04098549 Completed - Type 1 Diabetes Clinical Trials

The Effect of Rapid and Slow Glucose Fall on the Subsequent Glucose Production in People With Type 1 Diabetes

RaSlo-19
Start date: September 12, 2019
Phase: N/A
Study type: Interventional

In the effort of better understanding the glucose control in people with type 1 diabetes, in-depth insight into the physiology of hepatic glucose production and its influencing factors is essential. Previously, a number of potential influencing factors of hepatic glucose production have been investigated, including insulin-on-board, low carbohydrate diet, preceding ethanol intake, exercise and multiple stimulations of hepatic glucose production. Previous post-hoc analysis of dual-hormone closed-loop systems has indicated that the rate of fall in blood glucose influences the following stimulation of hepatic glucose response. However, the rate of fall in blood glucose is highly related to insulin levels, which may explain those findings. Thus, in this study the investigators want to examine whether the different rates of fall in blood glucose with similar insulin levels on board affect the hepatic glucose response in individuals with type 1 diabetes. In the study, which will be conducted at Steno Diabetes Center Copenhagen, participants will complete two study visits. On each visit, a hypoglycemic clamp technique will be used to lower the blood glucose levels of the participants (using either a rapid or slow decline rate), whereupon hepatic glucose production will be stimulated using low-dose glucagon. The study days are divided into four phases: 1) preparation phase, 2) hyperinsulinemic euglycemic phase (stabilization of blood glucose), 3) hyperinsulinemic hypoglycemic phase (rapid or slow decline in blood glucose) and 4) post-glucagon administration phase. This design will allow the investigators to examine whether differences in hepatic glucose response exist depending on preceding rate of fall in blood glucose. We hypothesize that the rate of fall in blood glucose does not affect the hepatic glucose production.

NCT ID: NCT04082923 Completed - Obesity Clinical Trials

Effect of Meal Texture on Glucose-metabolism and Gut Hormone Response After Bariatric Surgery

Obesity
Start date: October 3, 2019
Phase: N/A
Study type: Interventional

The investigators want to evaluate the difference in glucose metabolism and intestinal hormonal response after a liquid meal versus a solid meal in patients after bariatric surgery.

NCT ID: NCT04051294 Completed - Clinical trials for Glucose Metabolism Disorders (Including Diabetes Mellitus)

The Effect of Kombucha on Blood Sugar Levels in Humans

Start date: January 3, 2019
Phase: N/A
Study type: Interventional

As a phase 0 clinical trial, we will learn how kombucha influences glucose metabolism in humans.

NCT ID: NCT04042142 Completed - Clinical trials for Non-Alcoholic Fatty Liver Disease

Glucagon Resistance in Patients With NAFLD

Start date: October 5, 2019
Phase: N/A
Study type: Interventional

The investigators propose that the sensitivity to glucagon in hepatic lipid metabolism is impaired in subjects with non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH). Moreover, they propose a dys-coordinated, reduced glucagon sensitivity in hepatic lipid metabolism and endogen glucose production in patients with NAFLD and NASH compared with healthy subjects and patients with simple steatosis. This reduced sensitivity may be the basis of a more severe dyslipidemia and the production of increased concentrations of toxic lipid intermediates in plasma and muscle tissue. The study will include healthy subjects with obesity and subjects with simple steatosis and NASH, tested at basal glucagonemia and moderate hyperglucagonemia to mimic insulin resistant levels during simultaneous somatostatin infusion and replacement doses of insulin and growth hormone. Infusion of palmitate, VLDL-triglyceride and glucose tracers in combination with indirect calorimetry as well as skeletal and adipose tissue biopsies will be employed to assess free fatty acid and VLDL-triglyceride kinetics (turnover, and oxidation) and hepatic fatty acid-esterification.

NCT ID: NCT04004273 Completed - Obesity Clinical Trials

Diabetes, Exercise and Liver Fat (DELIVER)

(DELIVER)
Start date: October 30, 2018
Phase: N/A
Study type: Interventional

This randomised controlled trial will determine if exercise (150 - 200 min per week, 6 weeks) can beneficially modify liver fat quality in non alcohol fatty liver disease patients with type 2 diabetes mellitus (n = 26, 13 per group). Liver fat quality will be assessed via magnetic resonance (3T) spectroscopy (1H-MRS) using validated methods.

NCT ID: NCT03954873 Completed - Clinical trials for Glucose Metabolism Disorders

Glucagon-like Peptide 2 - a Glucose Dependent Glucagonotropic Hormone?

GLANCE
Start date: January 31, 2019
Phase: N/A
Study type: Interventional

Infusion of glucagon-like peptide 2 (GLP-2) during euglycaemia, hypoglycaemia and hyperglycaemia and evaluation of the effect on glucagon secretion in healthy subjects.

NCT ID: NCT03908294 Completed - Hepatitis C Clinical Trials

Change of Glucose Metabolism and Fibrosis Markers in Patients With Hepatitis C Under Treatment With Antiviral Agents

Start date: August 13, 2018
Phase:
Study type: Observational

Chronic hepatitis C infection is associated with changes of glucose metabolism end increased frequency of impaired glucose tolerance. This might be a additional risk factor for disease and fibrosis progression. The study aims to evaluate whether a therapy with direct-acting antiviral agents leading to a sustained virologic response directly impacts parameters reflecting glucose metabolism and fibrosis.