View clinical trials related to Global Health.
Filter by:The RESETTLE-IDPs study aims to address a critical yet neglected issue: the mental health crisis among internally displaced persons (IDPs) in Nigeria. Due to devastating conflicts and climate disasters, over 3 million Nigerians have been forcibly uprooted from their homes and communities, seeking shelter in overcrowded camps with limited resources. The trauma of displacement, coupled with the daily stressors of uncertainty, poverty, and loss, has led to an epidemic of mental health disorders among IDPs. Recent studies reveal alarming rates of depression, anxiety, PTSD and even suicidal ideation in this vulnerable population, far surpassing the national averages. Despite the overwhelming need, a severe gap remains in access to quality, culturally-sensitive mental health care and psychosocial support services for IDPs in Nigeria. The RESETTLE-IDPs program was meticulously designed to fill this gap by providing a comprehensive, evidence-based mental health intervention tailored to the unique experiences and challenges of Nigerian IDPs. At its core, RESETTLE-IDPs is a life skills education program that empowers displaced individuals with the knowledge, skills and strategies to cope with adversity, build resilience, and work towards personal and collective healing. The program covers essential topics such as stress management, effective communication, problem-solving, emotional regulation, health and hygiene, human rights, and more, all adapted to the local language, customs and displacement context. What sets RESETTLE-IDPs apart is its innovative use of two delivery approaches: in-person facilitated peer support groups and mobile phone-enabled virtual support groups. IDP camps will be randomly assigned to receive either the in-person or mobile-based intervention over a 12-month period. In the in-person format, groups of 10-12 participants will meet weekly with a trained facilitator to discuss the life skills curriculum, share experiences, practice new techniques, and foster solidarity and mutual aid. The mobile approach will utilize interactive WhatsApp messages, and digital content to deliver the same life skills education to IDPs, supplemented by virtual group chats and tele-counseling for peer support. By comparing the two delivery methods head-to-head, the study aims to determine their relative feasibility, acceptability, efficacy, and cost-effectiveness in improving mental health outcomes among IDPs. To rigorously evaluate the impact of RESETTLE-IDPs, the research team will collect comprehensive data on participants' mental health symptoms (depression, anxiety, PTSD, wellbeing), daily functioning, social connectedness, life skills acquisition, and implementation outcomes (enrollment, engagement, fidelity, satisfaction). Assessments will occur at baseline, mid-point, immediately post-intervention, and 6-months after completion to examine both the short and long-term effects. The study purposefully focuses on IDP youth (ages 12-24) and women, as these subgroups face disproportionate adversity and risks in displacement settings. Adolescents, whose developing brains are highly sensitive to trauma, often struggle with identity formation, social isolation, and educational disruptions that can have lifelong consequences without proper support. Women IDPs contend with staggering rates of gender-based violence, sexual coercion, exploitation, and abuse in camps, leading to severe psychological distress on top of displacement trauma. By targeting these marginalized groups, RESETTLE-IDPs seeks to dismantle entrenched inequities and break cycles of suffering. If proven effective, the RESETTLE-IDPs model could transform mental health services in humanitarian crises globally. By harnessing the power of mobile technology and peer support, this innovative, scalable, and culturally-adapted intervention has the potential to reach thousands of IDPs in remote and resource-limited settings. Beyond symptom reduction, RESETTLE-IDPs aims to nurture long-term psychosocial wellbeing, self-efficacy and reintegration by empowering displaced individuals to be change agents in their own lives and communities. Ultimately, the RESETTLE-IDPs study strives to generate evidence that can inform more holistic, dignified and sustainable humanitarian responses to the global crisis of forced displacement. Instead of perpetuating dependence on short-term material aid, RESETTLE-IDPs recognizes the untapped capacity of IDP communities to be active partners in their journey from surviving to thriving. If this Nigerian experiment is successful, it could inspire a paradigm shift in how the world assists and empowers the record 103 million forcibly displaced people to find hope and healing amidst the wounds of war and disaster. In a world where climate change and conflicts continue to uproot millions each year, the promise of the RESETTLE-IDPs intervention to build resilience and restore dignity could not be more urgent or profound.
Transfusion medicine is closely linked with safe surgery. Transfusion Camp is a multidisciplinary educational project aimed at improving transfusion medicine knowledge in physicians. The course has been piloted in Rwanda, showing improvement in participant knowledge and confidence, resulting in its recommended implementation into the medical school curriculum. This project aims to evaluate a multi-day Transfusion Camp course mandatory for graduating medical students and first-year interns practicing in district hospitals in Rwanda. Its implementation is evaluated through pre- and post-course testing, collecting participants' blood ordering practices following the course, and conducting participant interviews about barriers to safe transfusion medicine in their hospital.
Every year there are an estimated 230,000 childhood deaths from TB. There is an urgent need for novel tests for TB diagnosis in children under 15 years. The Rapid Research in Diagnostics Development for TB Network (R2D2 Kids) and the Assessing Diagnostics at Point-of-care for Tuberculosis in children (ADAPT for Kids) studies seek to reduce the burden of TB worldwide by evaluating faster, simpler, and less expensive TB triage and diagnostic tests for use in children.
Alcohol and other drug use is common among people living with HIV in South Africa and is associated with worse engagement in HIV care. There is evidence that healthcare workers in this setting, including community health workers who play a central role in re-engaging patients back into HIV care, exhibit stigmatizing behaviors towards HIV patients who use substances. In general, healthcare worker stigma towards alcohol and other drug use is associated with poorer treatment of patients who use substances, and in this setting, healthcare worker stigma towards alcohol and other drug use has been associated with worse patient engagement in HIV care. In the United States, peer recovery coaches (PRCs), who are trained individuals with lived substance use recovery experience, have helped patients who use substances engage in healthcare. Theoretically, integrating a PRC onto a healthcare team also increases healthcare worker contact with a person with substance use experience, which may be associated with lower stigma. Yet, a PRC model has not yet been tested in South African HIV care. Therefore, the purpose of this study is to develop and pilot a PRC model integrated into community-based primary care teams providing HIV services in South Africa. The study aims to compare a healthcare team with a PRC to a team without a PRC. The investigators will primarily assess the implementation of this PRC model and rates of patient re-engagement in care.
PVRI-GoDeep is a PH Meta-Registry, run under the umbrella of the Pulmonary Vascular Research Institute (PVRI). It merges anonymized PH patient related data from various local registries around the world run under the responsibility of PVRI members. It will be operated under the auspices of the University of Giessen/Giessen PH center. Combining deep phenotyping with worldwide outreach, PVRI-GoDeep aims to offer insights into specific geographical and ethnical profiles of PH, to deepen the epidemiological, clinical and molecular understanding of this disease and to promote strategies for improved individualized treatment of PH patients.
Aim The purpose of this study is to determine if the addition of the VAST Course to technical resuscitation skills training enhances healthcare providers' resuscitation performance in a resource-limited setting. Objectives The aims of this research will be achieved by meeting the following objectives: 1. Quantitative evaluation of study participants' resuscitation performance during a simulation scenario before ACLS course, immediately following ACLS course, immediately following VAST course, and at 4 months post training. 2. Qualitative exploration of the barriers and supports identified by course participants to implementing resuscitation in the workplace after resuscitation skills training through focus groups. New knowledge Lessons learned from this study will help inform the design and the implementation of resuscitation training programs in resource-limited settings. This has potential to improve resuscitation capacity in resource-limited settings leading to higher quality of care for patients.
The aim of this study is to describe the patient clinical profile, resource requirements, and health system dynamics in a field hospital during the second wave of the Coronavirus (COVID-19) pandemic, leading to the outbreak of viral severe acute respiratory syndrome (SARS-CoV-2 virus), in South Africa. By describing the field hospital in this unique setting, the investigators hope to provide an efficient guide to similar settings across low- and middle-income countries. This was a retrospective, single-center study. A total of 596 patients with confirmed COVID-19 were admitted to Mitchells Plain Hospital of Hope (MPHOH), Cape Town, South Africa, between January 1st and February 28th, 2021. Patient clinical characteristics, outcome, and resource allocation was collected. Daily hospital dynamics, including admissions, discharges, deaths and oxygen use was analyzed and compared to the local and national COVID-19 incidence rates.
Introduction Global surgery is a growing movement worldwide, but its expansion has not been quantified. Google Search is the most popular search engine worldwide, and Google Trends analyzes its queries to determine popularity trends. The investigators used Google Trends to analyze the regional and temporal popularity of global surgery (GS). Furthermore, the investigators compared GS with global health (GH) to understand if the two were correlated. Methods The investigators searched the terms "global surgery" and "global health" on Google Trends (Google Inc., CA, USA) from January 2004 to May 2021. The investigators identified time trends and compared the two search terms using SPSS v26 (IBM, WA, USA) to run summary descriptive analyses and Wilcoxon rank-sum tests.
Citizens of many countries are in the high peak period of the outbreak of the COVID-19 virus. People are currently struggling with the total cessation of certain aspects of normal life. The situation associated with the pandemic can lead to the development of many problems connected both with mental and physical health. The investigators, as psychologists, would like to better understand this difficult situation and identify mechanisms which can lead to health problems. Therefore, group of researchers and practitioners created this study to investigate how people in general cope with this critical situation. The researchers would like to estimate the following variables which participants will evaluate before and during the pandemic period: levels of physical activity, attitudes towards one's body, attitudes towards eating, and psychological well-being. The investigators would like to involve experts and scientists from all around the world. Through this research and by investigating how people cope with this critical situation the solutions for psychological care and interventions for global crisis situations like the COVID-19 pandemic might be identified.
Effective communication is a critical component of managing pandemic outbreaks like COVID-19. This study explores COVID-19 related public knowledge, perceptions, belief in public health recommendations, intent to comply with public health recommendations, trust in information sources and preferred information sources. Participants are invited to include detailed free-text answers to make sure their COVID-19 experiences are heard.