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Gingivitis clinical trials

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NCT ID: NCT05129878 Completed - Gingivitis Clinical Trials

Effect of EE/NETA With Scaling on Periodontium and hsCRP in PCOS Women With Gingivitis

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

As gingivitis is known to add to the systemic inflammatory burden and may consequently contribute to progression of PCOS and vice-versa, So, controlling local and systemic inflammatory burden by scaling g and medical treatment may have an effect in the management of PCOS women having gingivitis.There is no data as yet, comparing the impact of COCs along with scaling and COCs along with just oral hygiene instructions on the periodontal health of PCOS patients. Therefore, there is need to study the effect of combined oral contraceptives (ethinylestradiol/norethisterone acetate) along with scaling on periodontal status and high sensitivity C-Reactive Protein in polycystic ovary syndrome women having gingivitis

NCT ID: NCT05121909 Completed - Gingivitis Clinical Trials

A Study of Experimental Mouthwashes

Start date: November 15, 2021
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of experimental mouthwash formulations compared to a hydroalcohol control mouthwash and a positive control mouthwash for the reduction of gingivitis and plaque when used as an adjunct to tooth brushing during a twelve-week product usage period.

NCT ID: NCT05120141 Completed - Gingivitis Clinical Trials

A Twelve Week Study of Experimental Mouth Rinses

Start date: March 29, 2021
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of experimental mouth rinse formulations compared to a hydroalcohol control mouth rinse and a positive control mouth rinse for the reduction of gingivitis and plaque when used as an adjunct to tooth brushing during a twelve-week product usage period.

NCT ID: NCT05114681 Completed - Periodontitis Clinical Trials

Oral Health Care in Stroke Patients in Tertiary Care Hospital

Start date: January 1, 2021
Phase:
Study type: Observational [Patient Registry]

To investigate oral care provision in stroke care settings in Pakistan. Stroke can have adverse effects on oral care and health. Little is known about current oral care practices in stroke care settings.

NCT ID: NCT05113030 Completed - Clinical trials for Polycystic Ovary Syndrome

Impact of PCOS on Periodontal Status of Adolescent and Adult Age Group Women

Start date: November 1, 2021
Phase:
Study type: Observational

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women, primarily affecting the reproductive system, with substantial collateral negative health effects on metabolic, psychological, and cardiovascular functions. Patients with this syndrome are at higher risk of developing insulin resistance (IR), obesity, dyslipidemia, cardiovascular disease (CVD), and endometrial carcinoma.IR and hyperinsulinemia are responsible for the low-grade chronic systemic inflammation. Periodontitis, an immuno-inflammatory disease, is a result of interaction between bacterial attack and host inflammatory response, causing inflammation of supporting tissues of the teeth leading to tissue destruction and tooth loss. Chronic low-grade inflammation is emerging as a plausible etiologic mechanism linking periodontal disease and many systemic diseases. Previous cross-sectional studies described a possible relationship between PCOS and periodontitis and the impact of PCOS on gingival inflammation and vice-versa in terms of increased inflammatory markers (hsCRP, IL-6, IL-17 and TNF-α). In PCOS females, there is an alteration of various hormone levels in the body. Female sex steroid hormones play a key role in periodontal disease progression and periodontal and implant wound healing. Human gingiva has the capacity to metabolize hormones such as estrogen and progesterone. Moreover, gingival tissue exhibits receptors for such hormones and it is considered as a target organ for their direct action. These hormones might act on gingival cells by changing the effectiveness of the epithelial barrier to bacterial injury or by affecting the collagen maintenance and repair. To avoid periodontal implications as these hormonal changes can worsen the vulnerability to plaque-induced periodontal disease. So, present study is going to conduct in females with PCOS and periodontitis at different age groups like adolescent and adult age groups. AIM - Assessment of impact of polycystic ovary syndrome on periodontal status of women of adolescent and adult age groups.

NCT ID: NCT05101434 Completed - Stroke Clinical Trials

Gingivitis and Periodontitis as a Risk Factor for Stroke

Start date: January 10, 2021
Phase:
Study type: Observational [Patient Registry]

Periodontitis and gingivitis are one of the most infectious diseases in humans. Several studies have been carried out on the dependence of periodontitis and stroke. The aim of this study was to investigate gingivitis and periodontitis as risk factors for stroke in the Pakistani population.

NCT ID: NCT05073393 Completed - Dental Caries Clinical Trials

Effect of Probiotics on Oral Homeostasis During Sugar Stress

Start date: November 3, 2021
Phase: N/A
Study type: Interventional

The present study is a double-blinded randomized clinical trial with a duration of 28 days.

NCT ID: NCT05073107 Completed - Periodontitis Clinical Trials

The Effect of A Dental Application to Promote Self-Administered Plaque Control: A RCT

Start date: December 6, 2021
Phase: N/A
Study type: Interventional

Randomized Controlled Trial: to investigate the feasibility of the usage of a mobile dental application in the self-administration of plaque control in a two (2) parallel arm study with 52 subjects (n = 52). The study will take place over 2 visits (within 35 days): Visit 1 and 2. Prospective Open Cohort Study: Patients referred to the Periodontology Department will be invited to participate in the study during the Oral Hygiene Phase. Routine clinical indices will be recorded at Visit 1 and Visit 2 before active non-surgical periodontal treatment commences.

NCT ID: NCT05070507 Completed - Gingivitis Clinical Trials

Effect of an Enzyme-containing Lozenge on Dental Biofilm in Healthy Individuals.

Start date: January 8, 2021
Phase: N/A
Study type: Interventional

The purpose of the study is to assess the effect of an enzyme containing lozenge on dental plaque accumulation in healthy adults.

NCT ID: NCT05069246 Completed - Gingivitis Clinical Trials

The Clinical Assessment of Nigella Sativa Oil vs Chlorohexidine as a Therapeutic Aid for Gingivitis, Effect on Gingival IL-6 and IL-18 and Antimicrobial Efficacy.

Start date: December 8, 2020
Phase: Phase 2
Study type: Interventional

A double-blind randomized clinical trial was conducted for 14 days with 37 systemically healthy patients having chronic generalized gingivitis. The current study was designed to investigate the anti-inflammatory and antimicrobial efficacy of Nigella Sativa oil compared with chlorohexidine; assessing clinical parameters and gingival interleukin 6 (IL6) and interleukin 18 (IL18) levels and supra-gingival plaque analysis.