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Gingivitis clinical trials

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NCT ID: NCT05788692 Completed - Gingivitis Clinical Trials

Effectiveness of Toothbrushing Habits of Preschool Children, With or Without a Toothbrushing Assisting Application

Start date: February 15, 2023
Phase: N/A
Study type: Interventional

The aim of this study is to investigate the effectiveness of the use of a toothbrushing assisting mobile application in dental plaque removal and adherence to the toothbrushing routine, in preschool children (3-5 yrs old) when brushing with either manual or powered toothbrush. Objectives: To identify the effectiveness in dental plaque control in relation to the following parental characteristics: - Sociodemographic (area of residence, average income, education level) - Oral Health status - Oral Health Literacy - Parenting style - Parental oral hygiene practices

NCT ID: NCT05787600 Completed - Clinical trials for Periodontal Diseases

Anti-inflammatory and Anti-plaque Efficacies of Mouth Rinse Containing Hyaluronic Acid and Hydrogen Peroxide

Start date: March 3, 2023
Phase: Phase 3
Study type: Interventional

The goal of this clinical trial is to test efficiency of using mouth rinse containing (H2O2 and HA) over a period of two weeks to control on gingival inflammation and plaque accumulation through measuring the clinical periodontal parameters (Gingival Index (GI), Bleeding on probing (BOP) and modified Quigley-Hein Plaque Index (mQHPI ) in comparison with Chlorhexidine (CHX) and placebo mouth rinses in patients with biofilm induced gingivitis. Objectives: - Evaluate the clinical efficiency of using mouth rinse containing (H2O2 and HA) over a period of 14 days to control on gingival inflammation and plaque accumulation through measuring the clinical periodontal parameters (Gingival Index, Bleeding on probing and modified Quigley-Hein Plaque Index in comparison with Chlorhexidine and placebo mouth rinses in patients with biofilm induced gingivitis. - Measuring levels of salivary cytokines, Interleukin 1 beta (IL-1B) and Interleukin 6 (IL-6) at baseline visit before using mouth rinse and after 14 days of using the mouth rinse containing H2O2 and HA compared to chlorhexidine and placebo mouth rinses. - Evaluate subjects' perception of a mouth rinse (H2O2 and HA), CHX and placebo mouth rinses after 14 days from using three mouth rinse

NCT ID: NCT05766995 Completed - Gingivitis Clinical Trials

Evaluation of 3 Oral Self-care Regimens on Clinical Signs of Inflammation and Plaque

Start date: August 3, 2021
Phase: N/A
Study type: Interventional

To compare three different oral hygiene regimens on changes in gum tissue appearance, gum bleeding, and plaque scores.

NCT ID: NCT05731778 Completed - Gingivitis Clinical Trials

Clinical Study to Assess Therapeutic Delay and Resolution of Induced Gingivitis

Start date: December 22, 2018
Phase: Phase 4
Study type: Interventional

Evaluate a stannous technology for its effect on the neutrophil phenotype during an induced gingivitis state.

NCT ID: NCT05727436 Completed - Gingivitis; Chronic Clinical Trials

The Effect of Probiotics on Gingivitis

Start date: February 20, 2023
Phase: N/A
Study type: Interventional

The aim of the study is to assess the effect of oral probiotics containing Streptococcus salivarius M18 on gingivitis and oral hygiene in young adults.

NCT ID: NCT05709015 Completed - Gingivitis Clinical Trials

Plaque Inhibitory Effect of Neutral Electrolysed Water in the Form of a Mouthwash in a 4-day Non-brushing Model

Start date: January 5, 2023
Phase: Phase 2
Study type: Interventional

Electrolysed water (EOW) is produced by the electrolysis of sodium chloride in an aqueous solution, producing chlorine gas at the anode and sodium hydroxide and hydrogen at the cathode. EOW is known to have antimicrobial effects against various microorganisms, including viruses, bacteria, spores and fungi. Its antimicrobial activity is generally attributed to its hypochloric acid content - a product of chlorine gas dissolved in water. Due to its biocompatibility, known uses of EOW include ocular disinfection, nasal irrigation and chronic cutaneous wound care. In the dental setting, it may be used as a mouthwash, disinfectant, irrigant, mouthwash or dental gel. The aim of this study is to investigate the effect of a mouthwash containing neutral electrolyzed water on plaque accumulation (evaluated using a disclosing agent and an intraoral scanner), gingival inflammation, MMP-8 activity and the oral microbiome. In this double-blind, cross-over, 4-day experimental gingivitis model, each subject will participate in all three arms of the study. Each arm will last 4 days, during which the subjects will be asked to refrain from toothbrushing and the use of interdental cleaning devices. Instead, they will be instructed to rinse their oral cavities twice daily with either EOW, placebo or a positive control (chlorhexidine), according to a randomisation chart (each subject will receive a different mouthwash type in every arm of the study). The outcomes will be assessed at baseline and after 4 days. A washout period of at least 7 days will be implemented between each study arm.

NCT ID: NCT05654662 Completed - Gingivitis Clinical Trials

A Clinical Study Investigating the Effects of a Dentifrice Containing 67% Sodium Bicarbonate When Used Twice Daily for 12 Weeks on Gingivitis Treatment and Plaque Removal

Start date: February 20, 2023
Phase: N/A
Study type: Interventional

The main goal of this study is to evaluate and compare the efficacy of an on-market dentifrice containing 67 percent (%) sodium bicarbonate and 0.31% sodium fluoride to a reference regular fluoride dentifrice on treating gingival bleeding and gingival inflammation as well as reducing plaque accumulation in population with gingivitis after 12 weeks use.

NCT ID: NCT05623761 Completed - Gingivitis Clinical Trials

Toothpastes With Thermal Water for Oral Health

Start date: November 1, 2022
Phase: Phase 4
Study type: Interventional

The aim of the study is to compare the effect of toothpastes containing thermal water of Castera-Verduzan with 1450 ppm fluoride and without fluorinated derivatives on oral hygiene, gingivitis, and dentin hypersensitivity in young adults.

NCT ID: NCT05594004 Completed - Gingivitis Clinical Trials

A Meta-analysis Comparing Toothbrushes on Plaque Removal and Gingival Health

Start date: April 1, 2022
Phase:
Study type: Observational

The aim of this analysis was to compare gingivitis- and plaque-reduction efficacy from randomized controlled trials (RCTs) up to six months long evaluating oscillating-rotating, sonic, and manual toothbrushes

NCT ID: NCT05576610 Completed - Gingivitis Clinical Trials

The Effect of Enzyme-containing Mouth Spray on Oral Health Status and S.Mutans Levels in Paediatric Patients

Start date: July 31, 2023
Phase: N/A
Study type: Interventional

An interventional study was done on evaluating the Effect of Enzyme-containing Mouth Spray on Oral Health Status and S.Mutans levels in Paediatric Patients attending Hospital Universiti Sains Malaysia ( HUSM ) , Kelantan. This study compared the gingivitis score , plaque score and saliva bacteria count between the patients receiving a standard preventive advice alongside with normal saline mouth spray and those receiving standard preventive advice alongside with an enzyme containing mouth spray .