Gestational Diabetes Clinical Trial
Official title:
PDX-1 and NGN-3 Expression in Gestational Diabetes
Introduction: Depletion of the ability of the cells ß to secrete the amount of insulin
required by pregnancy, increasing the risk of develop Gestational Diabetes Mellitus (GDM).
The aim was to contrast the messenger RNA (mRNA) expression of the pancreatic duodenal
homeobox factor-1 (PDX-1) and Neurogenin-3 (Ngn-3) in peripheral blood of pregnant women with
GDM versus women with normal pregnancies.
Material and methods: This was a prospective, clinical and cross-sectional study, conforming
two groups of pregnant women: a) patients with a healthy gestation and b) patients with GDM.
Besides anthropometry and routine laboratorial test, real-time polymerase chain reaction
(Real-Time PCR), was used to quantify the expression of PDX-1 and NGN-3.
Pregnant women attended in the Maternal-Fetal Medicine Service of the "Mónica Pretelini
Sáenz" Maternal-Perinatal Hospital, were invited to participate. Those with autoimmune
diseases, heart disease, nephropathy, liver disease or any other chronic condition were
excluded and those with incomplete clinical files were discarded from the final analysis. Two
groups were integrated: a) patients with a healthy gestation and b) patients with GDM.
From all patients the next information was captured in an excell sheet: weight, height, Body
Mass Index, blood pressure, albumin, creatinine, electrolytes, glucose, total cholesterol,
triglycerides, transaminases and relative expression of PDX-1 and NGN-3.
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