Germ Cell Tumor Clinical Trial
Official title:
A Prospective Observational Cohort Study to Assess miRNA 371 for Outcome Prediction in Patients With Newly Diagnosed Germ Cell Tumors
This trial studies whether the blood marker micro ribonucleic acid (miRNA) 371 can predict the chance of cancer returning in patients with germ cell cancers. Studying samples of blood from patients with germ cell cancers in the laboratory may help doctors predict how likely the cancer will come back.
| Status | Recruiting |
| Enrollment | 956 |
| Est. completion date | October 1, 2026 |
| Est. primary completion date | June 1, 2026 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility | Inclusion Criteria: - Patients must have a new diagnosis of a germ cell tumor. confirmed pathologically or serologically (diagnostic elevation of human chorionic gonadotropin [HCG]/alpha-fetoprotein [AFP]). All primary sites, stages, histological subtypes of germ cell tumor are eligible. Metachronous second primary germ cell tumors are eligible - If surgery is planned, male patients with clinical stage I testicular cancer must have orchiectomy completed within 42 days prior to registration - Patients must be registered within 42 days after diagnosis and prior to initiation of a management plan or treatment for the disease - Patients must have initial imaging, laboratory and other clinical evaluations (see below) performed within 42 days prior to registration. Imaging reports, pathology reports and performance status will be collected - Patients must have beta-human chorionic gonadotropin (beta- HCG), alpha-fetoprotein (AFP), and lactate dehydrogenase (LDH) assessments within 42 days prior to registration - NOTE: If the patient had an orchiectomy prior to registration, report tumor marker values before and after surgery on the Baseline Tumor Marker form - Patients must have risk of relapse assessment determined by the local investigator prior to registration - Patients must agree to submit required specimens for defined translational medicine studies. These specimens are drawn at the same time as standard laboratory evaluations (beta-HCG, AFP, and LDH); NOTE: Ideally, patients should be willing to return to their center performing surveillance (registering site) for the duration of the study to ensure that specimens are timed to standard clinical observations (the registering site's surveillance schedule) - Patients must be offered participation in specimen banking for future research. With patient's consent, specimens must be submitted. - Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines - As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system |
| Country | Name | City | State |
|---|---|---|---|
| Canada | Tom Baker Cancer Centre | Calgary | Alberta |
| Canada | Cambridge Memorial Hospital | Cambridge | Ontario |
| Canada | Cross Cancer Institute | Edmonton | Alberta |
| Canada | QEII Health Sciences Centre/Nova Scotia Health Authority | Halifax | Nova Scotia |
| Canada | BCCA-Cancer Centre for the Southern Interior | Kelowna | British Columbia |
| Canada | London Regional Cancer Program | London | Ontario |
| Canada | Allan Blair Cancer Centre | Regina | Saskatchewan |
| Canada | Saskatoon Cancer Centre | Saskatoon | Saskatchewan |
| Canada | University Health Network-Princess Margaret Hospital | Toronto | Ontario |
| Canada | BCCA-Vancouver Cancer Centre | Vancouver | British Columbia |
| Canada | BCCA-Vancouver Island Cancer Centre | Victoria | British Columbia |
| Guam | FHP Health Center-Guam | Tamuning | |
| United States | Hawaii Cancer Care - Westridge | 'Aiea | Hawaii |
| United States | Pali Momi Medical Center | 'Aiea | Hawaii |
| United States | Queen's Cancer Center - Pearlridge | 'Aiea | Hawaii |
| United States | Straub Pearlridge Clinic | 'Aiea | Hawaii |
| United States | The Cancer Center of Hawaii-Pali Momi | 'Aiea | Hawaii |
| United States | The Queen's Medical Center - West Oahu | 'Ewa Beach | Hawaii |
| United States | Riverwood Healthcare Center | Aitkin | Minnesota |
| United States | University of New Mexico Cancer Center | Albuquerque | New Mexico |
| United States | Saint Anthony's Health | Alton | Illinois |
| United States | Kaiser Permanente-Anaheim | Anaheim | California |
| United States | Kaiser Permanente-Deer Valley Medical Center | Antioch | California |
| United States | PCR Oncology | Arroyo Grande | California |
| United States | Messino Cancer Centers | Asheville | North Carolina |
| United States | Duluth Clinic Ashland | Ashland | Wisconsin |
| United States | Northwest Wisconsin Cancer Center | Ashland | Wisconsin |
| United States | Rush - Copley Medical Center | Aurora | Illinois |
| United States | University of Colorado Hospital | Aurora | Colorado |
| United States | Kaiser Permanente-Baldwin Park | Baldwin Park | California |
| United States | Saint Louis Cancer and Breast Institute-Ballwin | Ballwin | Missouri |
| United States | Advocate Good Shepherd Hospital | Barrington | Illinois |
| United States | Bronson Battle Creek | Battle Creek | Michigan |
| United States | Essentia Health - Baxter Clinic | Baxter | Minnesota |
| United States | Nebraska Medicine-Bellevue | Bellevue | Nebraska |
| United States | Overlake Medical Center | Bellevue | Washington |
| United States | Kaiser Permanente-Bellflower | Bellflower | California |
| United States | Strecker Cancer Center-Belpre | Belpre | Ohio |
| United States | Sanford Joe Lueken Cancer Center | Bemidji | Minnesota |
| United States | Walter Reed National Military Medical Center | Bethesda | Maryland |
| United States | University of Iowa Healthcare Cancer Services Quad Cities | Bettendorf | Iowa |
| United States | Sanford Bismarck Medical Center | Bismarck | North Dakota |
| United States | Illinois CancerCare-Bloomington | Bloomington | Illinois |
| United States | Prisma Health Cancer Institute - Spartanburg | Boiling Springs | South Carolina |
| United States | Central Care Cancer Center - Bolivar | Bolivar | Missouri |
| United States | Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota |
| United States | Cox Cancer Center Branson | Branson | Missouri |
| United States | Keck Medicine of USC Buena Park | Buena Park | California |
| United States | Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin |
| United States | Illinois CancerCare-Canton | Canton | Illinois |
| United States | Saint Francis Medical Center | Cape Girardeau | Missouri |
| United States | Southeast Cancer Center | Cape Girardeau | Missouri |
| United States | Memorial Hospital of Carbondale | Carbondale | Illinois |
| United States | Saint Anthony Regional Hospital | Carroll | Iowa |
| United States | Carson Tahoe Regional Medical Center | Carson City | Nevada |
| United States | SIH Cancer Institute | Carterville | Illinois |
| United States | Illinois CancerCare-Carthage | Carthage | Illinois |
| United States | Centralia Oncology Clinic | Centralia | Illinois |
| United States | Saint Mary's Hospital | Centralia | Illinois |
| United States | Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania |
| United States | Cancer Specialists of Tidewater Limited | Chesapeake | Virginia |
| United States | Advocate Illinois Masonic Medical Center | Chicago | Illinois |
| United States | Northwestern University | Chicago | Illinois |
| United States | University of Chicago Comprehensive Cancer Center | Chicago | Illinois |
| United States | Adena Regional Medical Center | Chillicothe | Ohio |
| United States | Marshfield Clinic-Chippewa Center | Chippewa Falls | Wisconsin |
| United States | University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio |
| United States | Kaiser Sunnyside Medical Center | Clackamas | Oregon |
| United States | Columbus Oncology and Hematology Associates Inc | Columbus | Ohio |
| United States | Doctors Hospital | Columbus | Ohio |
| United States | Grant Medical Center | Columbus | Ohio |
| United States | Mount Carmel East Hospital | Columbus | Ohio |
| United States | Mount Carmel Health Center West | Columbus | Ohio |
| United States | Ohio State University Comprehensive Cancer Center | Columbus | Ohio |
| United States | Riverside Methodist Hospital | Columbus | Ohio |
| United States | The Mark H Zangmeister Center | Columbus | Ohio |
| United States | Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri |
| United States | AMG Crystal Lake - Oncology | Crystal Lake | Illinois |
| United States | Aurora Saint Luke's South Shore | Cudahy | Wisconsin |
| United States | Parkland Memorial Hospital | Dallas | Texas |
| United States | UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas |
| United States | Carle at The Riverfront | Danville | Illinois |
| United States | Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois |
| United States | Decatur Memorial Hospital | Decatur | Illinois |
| United States | Essentia Health - Deer River Clinic | Deer River | Minnesota |
| United States | Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Illinois |
| United States | Delaware Health Center-Grady Cancer Center | Delaware | Ohio |
| United States | Grady Memorial Hospital | Delaware | Ohio |
| United States | Broadlawns Medical Center | Des Moines | Iowa |
| United States | Iowa Lutheran Hospital | Des Moines | Iowa |
| United States | Iowa Methodist Medical Center | Des Moines | Iowa |
| United States | Medical Oncology and Hematology Associates-Des Moines | Des Moines | Iowa |
| United States | Essentia Health Saint Mary's - Detroit Lakes Clinic | Detroit Lakes | Minnesota |
| United States | Illinois CancerCare-Dixon | Dixon | Illinois |
| United States | Advocate Good Samaritan Hospital | Downers Grove | Illinois |
| United States | Columbus Oncology and Hematology Associates | Dublin | Ohio |
| United States | Dublin Methodist Hospital | Dublin | Ohio |
| United States | Epic Care-Dublin | Dublin | California |
| United States | Kaiser Permanente Dublin | Dublin | California |
| United States | Essentia Health Cancer Center | Duluth | Minnesota |
| United States | Essentia Health Saint Mary's Medical Center | Duluth | Minnesota |
| United States | Miller-Dwan Hospital | Duluth | Minnesota |
| United States | Prisma Health Cancer Institute - Easley | Easley | South Carolina |
| United States | Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin |
| United States | Carle Physician Group-Effingham | Effingham | Illinois |
| United States | Crossroads Cancer Center | Effingham | Illinois |
| United States | Advocate Sherman Hospital | Elgin | Illinois |
| United States | Christiana Care - Union Hospital | Elkton | Maryland |
| United States | Essentia Health - Ely Clinic | Ely | Minnesota |
| United States | Bay Area Breast Surgeons Inc | Emeryville | California |
| United States | Epic Care Partners in Cancer Care | Emeryville | California |
| United States | Essentia Health Cancer Center-South University Clinic | Fargo | North Dakota |
| United States | Sanford Broadway Medical Center | Fargo | North Dakota |
| United States | Sanford Medical Center Fargo | Fargo | North Dakota |
| United States | Sanford Roger Maris Cancer Center | Fargo | North Dakota |
| United States | Sanford South University Medical Center | Fargo | North Dakota |
| United States | Southpointe-Sanford Medical Center Fargo | Fargo | North Dakota |
| United States | Parkland Health Center - Farmington | Farmington | Missouri |
| United States | Lake Region Healthcare Corporation-Cancer Care | Fergus Falls | Minnesota |
| United States | Kaiser Permanente-Fontana | Fontana | California |
| United States | Cancer Care and Hematology-Fort Collins | Fort Collins | Colorado |
| United States | Poudre Valley Hospital | Fort Collins | Colorado |
| United States | Trinity Regional Medical Center | Fort Dodge | Iowa |
| United States | Mercy Hospital Fort Smith | Fort Smith | Arkansas |
| United States | Essentia Health - Fosston | Fosston | Minnesota |
| United States | Beebe South Coastal Health Campus | Frankford | Delaware |
| United States | Vanderbilt-Ingram Cancer Center Cool Springs | Franklin | Tennessee |
| United States | Kaiser Permanente-Fremont | Fremont | California |
| United States | Fresno Cancer Center | Fresno | California |
| United States | Kaiser Permanente-Fresno | Fresno | California |
| United States | Central Ohio Breast and Endocrine Surgery | Gahanna | Ohio |
| United States | Illinois CancerCare-Galesburg | Galesburg | Illinois |
| United States | Western Illinois Cancer Treatment Center | Galesburg | Illinois |
| United States | Central Care Cancer Center - Garden City | Garden City | Kansas |
| United States | Northwestern Medicine Cancer Center Delnor | Geneva | Illinois |
| United States | Aurora Health Care Germantown Health Center | Germantown | Wisconsin |
| United States | Banner MD Anderson Cancer Center | Gilbert | Arizona |
| United States | Peninsula Cancer Institute-Gloucester | Gloucester | Virginia |
| United States | Aurora Cancer Care-Grafton | Grafton | Wisconsin |
| United States | Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids | Michigan |
| United States | Spectrum Health at Butterworth Campus | Grand Rapids | Michigan |
| United States | Trinity Health Grand Rapids Hospital | Grand Rapids | Michigan |
| United States | Central Care Cancer Center - Great Bend | Great Bend | Kansas |
| United States | UCHealth Greeley Hospital | Greeley | Colorado |
| United States | Aurora BayCare Medical Center | Green Bay | Wisconsin |
| United States | Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin |
| United States | Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin |
| United States | Prisma Health Cancer Institute - Butternut | Greenville | South Carolina |
| United States | Prisma Health Cancer Institute - Eastside | Greenville | South Carolina |
| United States | Prisma Health Cancer Institute - Faris | Greenville | South Carolina |
| United States | Prisma Health Greenville Memorial Hospital | Greenville | South Carolina |
| United States | Prisma Health Cancer Institute - Greer | Greer | South Carolina |
| United States | Mount Carmel Grove City Hospital | Grove City | Ohio |
| United States | Zangmeister Center Grove City | Grove City | Ohio |
| United States | Kaiser Permanente - Harbor City | Harbor City | California |
| United States | Ingalls Memorial Hospital | Harvey | Illinois |
| United States | Essentia Health-Hayward Clinic | Hayward | Wisconsin |
| United States | Advocate South Suburban Hospital | Hazel Crest | Illinois |
| United States | Cancer and Blood Specialists-Henderson | Henderson | Nevada |
| United States | Comprehensive Cancer Centers of Nevada - Henderson | Henderson | Nevada |
| United States | Comprehensive Cancer Centers of Nevada-Horizon Ridge | Henderson | Nevada |
| United States | Comprehensive Cancer Centers of Nevada-Southeast Henderson | Henderson | Nevada |
| United States | GenesisCare USA - Henderson | Henderson | Nevada |
| United States | Las Vegas Cancer Center-Henderson | Henderson | Nevada |
| United States | Las Vegas Urology - Green Valley | Henderson | Nevada |
| United States | Las Vegas Urology - Pebble | Henderson | Nevada |
| United States | OptumCare Cancer Care at Seven Hills | Henderson | Nevada |
| United States | Urology Specialists of Nevada - Green Valley | Henderson | Nevada |
| United States | Essentia Health Hibbing Clinic | Hibbing | Minnesota |
| United States | UCHealth Highlands Ranch Hospital | Highlands Ranch | Colorado |
| United States | Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu | Hawaii |
| United States | Hawaii Cancer Care Inc-Liliha | Honolulu | Hawaii |
| United States | Hawaii Diagnostic Radiology Services LLC | Honolulu | Hawaii |
| United States | Island Urology | Honolulu | Hawaii |
| United States | Kaiser Permanente Moanalua Medical Center | Honolulu | Hawaii |
| United States | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii |
| United States | Kuakini Medical Center | Honolulu | Hawaii |
| United States | Queen's Cancer Cenrer - POB I | Honolulu | Hawaii |
| United States | Queen's Cancer Center - Kuakini | Honolulu | Hawaii |
| United States | Queen's Medical Center | Honolulu | Hawaii |
| United States | Straub Clinic and Hospital | Honolulu | Hawaii |
| United States | The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii |
| United States | University of Hawaii Cancer Center | Honolulu | Hawaii |
| United States | Keck Medicine of USC Huntington Beach | Huntington Beach | California |
| United States | Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana |
| United States | Essentia Health - International Falls Clinic | International Falls | Minnesota |
| United States | University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa |
| United States | Kaiser Permanente-Irvine | Irvine | California |
| United States | University of Mississippi Medical Center | Jackson | Mississippi |
| United States | Essentia Health - Jamestown Clinic | Jamestown | North Dakota |
| United States | Capital Region Southwest Campus | Jefferson City | Missouri |
| United States | Freeman Health System | Joplin | Missouri |
| United States | Mercy Hospital Joplin | Joplin | Missouri |
| United States | Straub Medical Center - Kahului Clinic | Kahului | Hawaii |
| United States | Castle Medical Center | Kailua | Hawaii |
| United States | Ascension Borgess Cancer Center | Kalamazoo | Michigan |
| United States | Borgess Medical Center | Kalamazoo | Michigan |
| United States | Bronson Methodist Hospital | Kalamazoo | Michigan |
| United States | West Michigan Cancer Center | Kalamazoo | Michigan |
| United States | Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin |
| United States | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois |
| United States | Kingman Regional Medical Center | Kingman | Arizona |
| United States | UC San Diego Moores Cancer Center | La Jolla | California |
| United States | Marshfield Clinic - Ladysmith Center | Ladysmith | Wisconsin |
| United States | Northwestern Medicine Lake Forest Hospital | Lake Forest | Illinois |
| United States | Northwell Health/Center for Advanced Medicine | Lake Success | New York |
| United States | Fairfield Medical Center | Lancaster | Ohio |
| United States | Alliance for Childhood Diseases/Cure 4 the Kids Foundation | Las Vegas | Nevada |
| United States | Ann M Wierman MD LTD | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada - Northwest | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada - Town Center | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada-Summerlin | Las Vegas | Nevada |
| United States | Desert West Surgery | Las Vegas | Nevada |
| United States | GenesisCare USA - Fort Apache | Las Vegas | Nevada |
| United States | GenesisCare USA - Las Vegas | Las Vegas | Nevada |
| United States | GenesisCare USA - Vegas Tenaya | Las Vegas | Nevada |
| United States | Hope Cancer Care of Nevada | Las Vegas | Nevada |
| United States | Las Vegas Cancer Center-Medical Center | Las Vegas | Nevada |
| United States | Las Vegas Prostate Cancer Center | Las Vegas | Nevada |
| United States | Las Vegas Urology - Cathedral Rock | Las Vegas | Nevada |
| United States | Las Vegas Urology - Pecos | Las Vegas | Nevada |
| United States | Las Vegas Urology - Smoke Ranch | Las Vegas | Nevada |
| United States | Las Vegas Urology - Sunset | Las Vegas | Nevada |
| United States | OptumCare Cancer Care at Charleston | Las Vegas | Nevada |
| United States | OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada |
| United States | OptumCare Cancer Care at MountainView | Las Vegas | Nevada |
| United States | Radiation Oncology Centers of Nevada Central | Las Vegas | Nevada |
| United States | Radiation Oncology Centers of Nevada Southeast | Las Vegas | Nevada |
| United States | Summerlin Hospital Medical Center | Las Vegas | Nevada |
| United States | Sunrise Hospital and Medical Center | Las Vegas | Nevada |
| United States | University Cancer Center | Las Vegas | Nevada |
| United States | University Medical Center of Southern Nevada | Las Vegas | Nevada |
| United States | Urology Specialists of Nevada - Central | Las Vegas | Nevada |
| United States | Urology Specialists of Nevada - Northwest | Las Vegas | Nevada |
| United States | Urology Specialists of Nevada - Southwest | Las Vegas | Nevada |
| United States | Beebe Medical Center | Lewes | Delaware |
| United States | Wilcox Memorial Hospital and Kauai Medical Clinic | Lihue | Hawaii |
| United States | Saint Rita's Medical Center | Lima | Ohio |
| United States | Loma Linda University Medical Center | Loma Linda | California |
| United States | Kaiser Permanente Los Angeles Medical Center | Los Angeles | California |
| United States | Kaiser Permanente West Los Angeles | Los Angeles | California |
| United States | Keck Medicine of USC Koreatown | Los Angeles | California |
| United States | Los Angeles County-USC Medical Center | Los Angeles | California |
| United States | UCLA / Jonsson Comprehensive Cancer Center | Los Angeles | California |
| United States | USC / Norris Comprehensive Cancer Center | Los Angeles | California |
| United States | Medical Center of the Rockies | Loveland | Colorado |
| United States | Illinois CancerCare-Macomb | Macomb | Illinois |
| United States | OhioHealth Mansfield Hospital | Mansfield | Ohio |
| United States | Marietta Memorial Hospital | Marietta | Ohio |
| United States | Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin |
| United States | OhioHealth Marion General Hospital | Marion | Ohio |
| United States | Marshfield Medical Center-Marshfield | Marshfield | Wisconsin |
| United States | Contra Costa Regional Medical Center | Martinez | California |
| United States | Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois |
| United States | LSU Healthcare Network / Metairie Multi-Specialty Clinic | Metairie | Louisiana |
| United States | Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin |
| United States | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin |
| United States | Aurora Sinai Medical Center | Milwaukee | Wisconsin |
| United States | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin |
| United States | Kaiser Permanente-Modesto | Modesto | California |
| United States | Essentia Health - Moose Lake Clinic | Moose Lake | Minnesota |
| United States | Good Samaritan Regional Health Center | Mount Vernon | Illinois |
| United States | Knox Community Hospital | Mount Vernon | Ohio |
| United States | Trinity Health Muskegon Hospital | Muskegon | Michigan |
| United States | Vanderbilt Breast Center at One Hundred Oaks | Nashville | Tennessee |
| United States | Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee |
| United States | Mount Carmel New Albany Surgical Hospital | New Albany | Ohio |
| United States | Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey |
| United States | UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois |
| United States | Louisiana State University Health Science Center | New Orleans | Louisiana |
| United States | Christiana Care Health System-Christiana Hospital | Newark | Delaware |
| United States | Delaware Clinical and Laboratory Physicians PA | Newark | Delaware |
| United States | Helen F Graham Cancer Center | Newark | Delaware |
| United States | Licking Memorial Hospital | Newark | Ohio |
| United States | Medical Oncology Hematology Consultants PA | Newark | Delaware |
| United States | Newark Radiation Oncology | Newark | Ohio |
| United States | UCI Health Newport -- Birch Street | Newport Beach | California |
| United States | USC Norris Oncology/Hematology-Newport Beach | Newport Beach | California |
| United States | Peninsula Cancer Institute-Newport News | Newport News | Virginia |
| United States | Lakeland Hospital Niles | Niles | Michigan |
| United States | Cancer and Hematology Centers of Western Michigan - Norton Shores | Norton Shores | Michigan |
| United States | Cancer Care Center of O'Fallon | O'Fallon | Illinois |
| United States | Advocate Christ Medical Center | Oak Lawn | Illinois |
| United States | Alta Bates Summit Medical Center - Summit Campus | Oakland | California |
| United States | Bay Area Tumor Institute | Oakland | California |
| United States | Kaiser Permanente Oakland-Broadway | Oakland | California |
| United States | Kaiser Permanente-Oakland | Oakland | California |
| United States | Saint Vincent Hospital Cancer Center at Oconto Falls | Oconto Falls | Wisconsin |
| United States | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma |
| United States | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma |
| United States | Nebraska Medicine-Village Pointe | Omaha | Nebraska |
| United States | University of Nebraska Medical Center | Omaha | Nebraska |
| United States | Kaiser Permanente-Ontario | Ontario | California |
| United States | UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California |
| United States | Northwestern Medicine Orland Park | Orland Park | Illinois |
| United States | University of Chicago Medicine-Orland Park | Orland Park | Illinois |
| United States | Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin |
| United States | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois |
| United States | Hope Cancer Care of Nevada-Pahrump | Pahrump | Nevada |
| United States | Kaiser Permanente - Panorama City | Panorama City | California |
| United States | Essentia Health - Park Rapids | Park Rapids | Minnesota |
| United States | Advocate Lutheran General Hospital | Park Ridge | Illinois |
| United States | Keck Medical Center of USC Pasadena | Pasadena | California |
| United States | Illinois CancerCare-Pekin | Pekin | Illinois |
| United States | Capital Health Medical Center-Hopewell | Pennington | New Jersey |
| United States | Illinois CancerCare-Peoria | Peoria | Illinois |
| United States | Methodist Medical Center of Illinois | Peoria | Illinois |
| United States | Mercy Health Perrysburg Cancer Center | Perrysburg | Ohio |
| United States | Illinois CancerCare-Peru | Peru | Illinois |
| United States | Valley Radiation Oncology | Peru | Illinois |
| United States | University of Pennsylvania/Abramson Cancer Center | Philadelphia | Pennsylvania |
| United States | Kaiser Permanente Northwest | Portland | Oregon |
| United States | Oregon Health and Science University | Portland | Oregon |
| United States | Southern Ohio Medical Center | Portsmouth | Ohio |
| United States | Illinois CancerCare-Princeton | Princeton | Illinois |
| United States | Aurora Cancer Care-Racine | Racine | Wisconsin |
| United States | Kaiser Permanente-Rancho Cordova Cancer Center | Rancho Cordova | California |
| United States | Kaiser Permanente- Marshall Medical Offices | Redwood City | California |
| United States | Kaiser Permanente-Redwood City | Redwood City | California |
| United States | Spectrum Health Reed City Hospital | Reed City | Michigan |
| United States | Beebe Health Campus | Rehoboth Beach | Delaware |
| United States | Radiation Oncology Associates | Reno | Nevada |
| United States | Renown Regional Medical Center | Reno | Nevada |
| United States | Saint Mary's Regional Medical Center | Reno | Nevada |
| United States | Valley Medical Center | Renton | Washington |
| United States | Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin |
| United States | Kaiser Permanente-Richmond | Richmond | California |
| United States | VCU Massey Cancer Center at Stony Point | Richmond | Virginia |
| United States | Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia |
| United States | Kaiser Permanente-Riverside | Riverside | California |
| United States | University of Rochester | Rochester | New York |
| United States | Rohnert Park Cancer Center | Rohnert Park | California |
| United States | Delbert Day Cancer Institute at PCRMC | Rolla | Missouri |
| United States | Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri |
| United States | Kaiser Permanente-Roseville | Roseville | California |
| United States | The Permanente Medical Group-Roseville Radiation Oncology | Roseville | California |
| United States | Kaiser Permanente Downtown Commons | Sacramento | California |
| United States | Kaiser Permanente-South Sacramento | Sacramento | California |
| United States | South Sacramento Cancer Center | Sacramento | California |
| United States | Heartland Regional Medical Center | Saint Joseph | Missouri |
| United States | Lakeland Medical Center Saint Joseph | Saint Joseph | Michigan |
| United States | Marie Yeager Cancer Center | Saint Joseph | Michigan |
| United States | Mercy Hospital Saint Louis | Saint Louis | Missouri |
| United States | Mercy Hospital South | Saint Louis | Missouri |
| United States | Missouri Baptist Medical Center | Saint Louis | Missouri |
| United States | Saint Louis Cancer and Breast Institute-South City | Saint Louis | Missouri |
| United States | Siteman Cancer Center at Christian Hospital | Saint Louis | Missouri |
| United States | Siteman Cancer Center-South County | Saint Louis | Missouri |
| United States | Washington University School of Medicine | Saint Louis | Missouri |
| United States | Siteman Cancer Center at Saint Peters Hospital | Saint Peters | Missouri |
| United States | Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri |
| United States | Salem Hospital | Salem | Oregon |
| United States | Kaiser Permanente-San Diego Mission | San Diego | California |
| United States | Kaiser Permanente-San Diego Zion | San Diego | California |
| United States | UC San Diego Medical Center - Hillcrest | San Diego | California |
| United States | Kaiser Permanente-San Francisco | San Francisco | California |
| United States | Kaiser Permanente-Santa Teresa-San Jose | San Jose | California |
| United States | Kaiser Permanente San Leandro | San Leandro | California |
| United States | Kaiser Permanente-San Marcos | San Marcos | California |
| United States | Kaiser San Rafael-Gallinas | San Rafael | California |
| United States | Essentia Health Sandstone | Sandstone | Minnesota |
| United States | Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California |
| United States | Kaiser Permanente-Santa Rosa | Santa Rosa | California |
| United States | Virginia Mason Medical Center | Seattle | Washington |
| United States | Prisma Health Cancer Institute - Seneca | Seneca | South Carolina |
| United States | Saint Vincent Hospital Cancer Center at Sheboygan | Sheboygan | Wisconsin |
| United States | Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin |
| United States | Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota |
| United States | Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota |
| United States | Kaiser Permanente Cancer Treatment Center | South San Francisco | California |
| United States | Kaiser Permanente-South San Francisco | South San Francisco | California |
| United States | Essentia Health-Spooner Clinic | Spooner | Wisconsin |
| United States | CoxHealth South Hospital | Springfield | Missouri |
| United States | Memorial Medical Center | Springfield | Illinois |
| United States | Mercy Hospital Springfield | Springfield | Missouri |
| United States | Southern Illinois University School of Medicine | Springfield | Illinois |
| United States | Springfield Clinic | Springfield | Illinois |
| United States | Springfield Regional Medical Center | Springfield | Ohio |
| United States | Marshfield Medical Center-River Region at Stevens Point | Stevens Point | Wisconsin |
| United States | Kaiser Permanente-Stockton | Stockton | California |
| United States | Saint Vincent Hospital Cancer Center at Sturgeon Bay | Sturgeon Bay | Wisconsin |
| United States | Cancer Specialists of Tidewater-Suffolk | Suffolk | Virginia |
| United States | Missouri Baptist Sullivan Hospital | Sullivan | Missouri |
| United States | Aurora Medical Center in Summit | Summit | Wisconsin |
| United States | Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri |
| United States | Essentia Health Saint Mary's Hospital - Superior | Superior | Wisconsin |
| United States | Southwest Illinois Health Services LLP | Swansea | Illinois |
| United States | Sanford Thief River Falls Medical Center | Thief River Falls | Minnesota |
| United States | Mercy Health - Saint Anne Hospital | Toledo | Ohio |
| United States | Saint Vincent Mercy Medical Center | Toledo | Ohio |
| United States | Munson Medical Center | Traverse City | Michigan |
| United States | Banner University Medical Center - Tucson | Tucson | Arizona |
| United States | University of Arizona Cancer Center-North Campus | Tucson | Arizona |
| United States | University of Arizona Cancer Center-Orange Grove Campus | Tucson | Arizona |
| United States | Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin |
| United States | Carle Cancer Center | Urbana | Illinois |
| United States | The Carle Foundation Hospital | Urbana | Illinois |
| United States | Kaiser Permanente Medical Center-Vacaville | Vacaville | California |
| United States | Kaiser Permanente-Vallejo | Vallejo | California |
| United States | Essentia Health Virginia Clinic | Virginia | Minnesota |
| United States | Peninsula Cancer Institute-Cancer Specialists of Tidewater | Virginia Beach | Virginia |
| United States | Epic Care Cyberknife Center | Walnut Creek | California |
| United States | Kaiser Permanente-Walnut Creek | Walnut Creek | California |
| United States | Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois |
| United States | Illinois CancerCare - Washington | Washington | Illinois |
| United States | Mercy Hospital Washington | Washington | Missouri |
| United States | Marshfield Clinic-Wausau Center | Wausau | Wisconsin |
| United States | Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin |
| United States | Aurora West Allis Medical Center | West Allis | Wisconsin |
| United States | University of Cincinnati Cancer Center-West Chester | West Chester | Ohio |
| United States | Methodist West Hospital | West Des Moines | Iowa |
| United States | Saint Ann's Hospital | Westerville | Ohio |
| United States | Marshfield Medical Center - Weston | Weston | Wisconsin |
| United States | Peninsula Cancer Institute-Williamsburg | Williamsburg | Virginia |
| United States | Christiana Care Health System-Wilmington Hospital | Wilmington | Delaware |
| United States | Marshfield Clinic - Wisconsin Rapids Center | Wisconsin Rapids | Wisconsin |
| United States | Kaiser Permanente-Woodland Hills | Woodland Hills | California |
| United States | Sanford Cancer Center Worthington | Worthington | Minnesota |
| United States | University of Michigan Health - West | Wyoming | Michigan |
| United States | North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima | Washington |
| United States | Rush-Copley Healthcare Center | Yorkville | Illinois |
| United States | Genesis Healthcare System Cancer Care Center | Zanesville | Ohio |
| Lead Sponsor | Collaborator |
|---|---|
| SWOG Cancer Research Network | National Cancer Institute (NCI) |
United States, Canada, Guam,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | To estimate positive predictive value of miRNA 371 in early stage testicular seminoma and nonseminoma patients | Positive predictive value will be estimated using plasma miRNA 371 expression at relapse. | Up to 3 years | |
| Primary | To bank blood specimens of patients at low risk and moderate risk of relapse | 10 ml whole blood will be collected at time points specified by the protocol. | Up to 3 years |
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