Impact of a Family History of Hypertension and Physical Activity on Left Ventricular Mass

Genetic Predisposition Clinical Trial

Official title:

Impact of a Family History of Hypertension and Physical Activity on Left Ventricular Mass

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05334355
• Other study ID #: IRB-FY15-16-185 & 19-20-1602
• Status: Completed
• Start date: April 19, 2016
• Est. completion date: February 27, 2020

Study information

• Verified date: April 2022
• Source: Montclair State University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This is a retrospective analysis of data collected within two previous studies. The data has been combined and used to investigate the impact of having a family history of hypertension on left ventricular muscle mass with and without controlling for moderate and vigorous intensity physical activity frequency per week. The hypothesis was that in a sample of mostly active participants, no differences in left ventricular mass between family history of hypertension groups would be observed, but the positive family history of hypertension group would have elevated left ventricular mass compared to the negative family history of hypertension group following statistical control of activity frequency.

Description:

A positive family history of hypertension (FHH) (+FHH) is associated with elevated left ventricular mass (LVM). Regular physical activity (PA) may eliminate differences in LVM between +FHH and negative family history of hypertension (-FHH) adults. PURPOSE: To determine if a +FHH is associated with a greater LVM compared to a -FHH group within a sample of young, mostly active healthy adults with and without statistically controlling for PA. METHODS: Healthy young (18-32yrs) participants self-reported FHH status and habitual moderate and vigorous PA frequency. Participants then underwent an echocardiogram.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 61
• Est. completion date: February 27, 2020
• Est. primary completion date: February 27, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 32 Years

Eligibility

Inclusion Criteria:

• Generally healthy

Exclusion Criteria:

• Known hypertension, cardiovascular disease, current pregnancy, current infectious disease, diabetes mellitus, kidney disease, a history of cancer, pulmonary disease, history of a stroke, obesity (for most people this means a body mass index greater than 30), or any life threatening chronic conditions

Related Conditions & MeSH terms

• Disease Susceptibility
• Genetic Hypertension
• Genetic Predisposition
• Genetic Predisposition to Disease
• Hypertension

Intervention

Other:
• Family history of hypertension
Presence or absence of a family history of hypertension in a cross sectional study design.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Montclair State University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Left Ventricular Mass	Muscle mass in grams of the left ventricle of the heart as estimated by ultrasound.	Day 2