Genetic Investigation of Cancer Predisposition

Status Not yet recruiting

Clinical Trial Summary

Clinical information and samples (blood, saliva, and tumor) will be collected from patients with multiple cancers and/or a family history of cancer as well as from affected and unaffected relatives; samples will be systematically sequenced and evaluated for candidate driver mutations.

Clinical Trial Description

Genetic screening will be performed on DNA (and/or RNA) isolated from collected samples from affected individuals by whole exome sequencing or RNA sequencing using in-house pipeline to identify candidate sequence variants. These variants will be tested for segregation with the phenotype in other relatives (affected/unaffected). Candidate variants will be subjected to additional downstream analysis, to be guided by the actual type of gene/variant. ;

Study Design

Related Conditions & MeSH terms

Cancer
Disease Susceptibility
Genetic Predisposition
Genetic Predisposition to Disease

Clinical Trial Details

NCT number	NCT04620278
Study type	Observational [Patient Registry]
Source	The University of Texas Health Science Center at San Antonio
Contact	Patricia L Dahia, MD, PhD
Phone	210-567-4866
Email	dahia@uthscsa.edu
Status	Not yet recruiting
Phase
Start date	October 2024
Completion date	December 2035

View Details

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