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Genetic Anticipation clinical trials

View clinical trials related to Genetic Anticipation.

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NCT ID: NCT05825183 Recruiting - Clinical trials for Genetic Anticipation

Study of Product of Conception Derived From Ultrasound-guided Manual Vacuum Aspiration

Start date: May 30, 2023
Phase:
Study type: Observational

Early pregnancy loss is very common, approximately one in four women will experience a miscarriage in their lifetime. The etiology of pregnancy loss remains largely unknown, although genetic, anatomical, endocrinological and immunological abnormalities have been implicated. It is known that embryonic/fetal chromosomal aberrations contributed to approximately 50% of early pregnancy loss, among which 60-70% were aneuploidies, largely can be detected by the current gold standard karyotyping approach recommended by various international societies. However, the drawbacks of conventional karyotyping include the risk of culture failure, maternal cell contamination (MCC), limited detection resolution (5-10 Mb), and differential growth of specific cell lineages which could hinder the diagnosis of genetic abnormalities, particularly mosaicisms. Additional genetic factors beyond the resolution of karyotyping are not well studied.

NCT ID: NCT03063216 Recruiting - Congenital Cataract Clinical Trials

Shanghai Pediatric Cataract Study

Start date: January 1, 2009
Phase:
Study type: Observational [Patient Registry]

The purpose of this study is to evaluate the long-term visual outcome of the cataract surgery using a large-scale and comprehensive database of pediatric cataract participants, including congenital and traumatic cataract. The investigators will further investigate into the various genetic and environmental factors that may contribute to the pathogenesis of pediatric cataract.

NCT ID: NCT03062085 Recruiting - Cataract Clinical Trials

Shanghai High Myopia Study

Start date: January 1, 2015
Phase:
Study type: Observational [Patient Registry]

The purpose of this study is to evaluate the long-term visual outcome of the cataract surgery using a large-scale and comprehensive database of high myopic cataract and age-related cataract patients. The investigators will further investigate into the various genetic and environmental factors that may contribute to the pathogenesis of high myopic cataract.