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Generalized Anxiety Disorder clinical trials

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NCT ID: NCT03702803 Recruiting - Clinical trials for Generalized Anxiety Disorder

Efficacy and Safety Study of a IMSS Developed Phytopharmaceutical for the Treatment of Anxiety.

Alpra
Start date: March 16, 2016
Phase: Phase 2
Study type: Interventional

The investigator's group at the Mexican Institute of Social Security has worked for more than 20 years in the scientific research of the plant species Galphimia glauca Cav., which is used in Mexican Traditional Medicine for the treatment of mental disorders. With the obtained results it was possible the development of a phytopharmaceutical elaborated with the extract of this plant, which was standardized in its content of Galphimine-B (G-B). This new compound is a nor, seco-triterpene, which possesses selective effects on the central nervous system. Through electrophysiological neuronal unitary records it was identified that G-B acts on the ventral tegmental area (VTA), and exerts its effect on (N-methyl-D-aspartate) NMDA receptors in dopaminergic neurons. The new phytopharmaceutical, elaborated from a standardized extract (in its G-B content) of G. glauca, was subjected to a double blind and randomized clinical study that compared its efficacy and therapeutic tolerability with a similar drug formulated with lorazepam in patients with diagnosis of generalized anxiety disorder (GAD). In a total of 152 patients, it was evidenced that the phytomedicine administered orally (for 4 weeks) was able to significantly reduce anxiety, in a similar way as lorazepam did, but with better tolerability. Several patients who were treated with lorazepam had to leave the study because they had daytime sleepiness. In clinical practice, different benzodiazepines have specific indications. In the case of anxiety disorders, the drug of first choice is Alprazolam, this, because it manifests a more powerful anxiolytic effect with a lower degree of sedation and daytime sleepiness. Objective: The present project aims to compare the efficacy and therapeutic safety of an elaborated phytopharmaceutical with the standardized extract of Galphimia glauca with Alprazolam .

NCT ID: NCT03549819 Recruiting - Clinical trials for Generalized Anxiety Disorder

Cannabidiol for the Treatment of Anxiety Disorders: An 8-Week Pilot Study

Start date: December 15, 2021
Phase: Phase 3
Study type: Interventional

This proposed study aims to evaluate the efficacy of daily Cannabidiol (CBD) Oil Capsules in treating symptoms of DSM-5 anxiety disorders, using a two-arm, 8-week randomized, placebo-controlled trial in adults aged 21-65 years. The study will also evaluate the relationship between inflammation, anxiety and CBD using biological markers as well as examine the neuro-cognitive effects of CBD treatment.

NCT ID: NCT03528109 Recruiting - Anxiety Clinical Trials

Improving Access to Child Anxiety Treatment

IMPACT
Start date: July 1, 2018
Phase: N/A
Study type: Interventional

There is strong evidence that cognitive behavioral therapy (CBT) with exposure is the preferred treatment for youth with anxiety disorders, but outpatient services that provide this type of treatment are limited. Even for those who do have access to anxiety-specific treatment, a traditional outpatient model of treatment delivery may not be suitable. Among the numerous logistical barriers to treatment access and response is the inability to generalize treatment tools to settings outside of the office. Patient-centered (home-based or telehealth; patient-centered telehealth closed as of 5/1/21) treatment models that target symptoms in the context in which they occur could be more effective, efficient, and accessible for families. The present study aims to compare the efficacy, efficiency, and feasibility of patient centered home-based CBT and patient centered telehealth CBT with a traditional office-based model of care. The question proposed, including proposed outcomes, have been generated and developed by a group of hospital, payer, patient and family stakeholders who will also contribute to the iterative process of protocol revision. The investigators anticipate 379 anxious youth to be randomized to receive outpatient treatment using telehealth (patient-centered telehealth closed as of 5/1/21), home-based services, or treatment as usual using a traditional outpatient model. Results of this study are expected to provide evidence for the efficacy and efficiency of patient-centered treatment, as well as increase treatment access and family engagement in the treatment process.

NCT ID: NCT03507114 Recruiting - Depression Clinical Trials

Rumination Focus Cognitive Behavior Therapy

iRFCBT
Start date: March 27, 2018
Phase: N/A
Study type: Interventional

1. To investigate the efficacy and acceptability of a guided internet-delivered transdiagnostic intervention targeting repetitive negative thinking for individuals with elevated levels of depression and generalized anxiety disorder (mild to moderate clinical symptoms) vs a wait-list control group (WLCG). 2. To investigate the hypothesized mechanism of change: Repetitive negative thinking is reduced first, and consequently the clinical symptoms (depression and/or anxiety) decrease.

NCT ID: NCT03329287 Recruiting - Clinical trials for Major Depressive Disorder

Simplified Cognitive Behavioral Therapy for Generalized Anxiety Disorder and Depression

Start date: July 1, 2017
Phase: N/A
Study type: Interventional

This trial attempts to evaluate the treatment efficacy of Simplified Cognitive Behavioral Therapy (SCBT) and its safety among schizophrenia patients. Half of participants will be randomized to accept SCBT.

NCT ID: NCT02739607 Recruiting - Depression Clinical Trials

Internet-delivered Transdiagnostic Intervention for Anxiety and Depression

iTAD
Start date: April 2016
Phase: N/A
Study type: Interventional

Objectives 1. To test the effectiveness and acceptability of an augmented internet-supported transdiagnostic intervention in Romania. 2. To assess the cost-effectiveness of the Internet version of the transdiagnostic program as compared to a standard treatment/usual care.

NCT ID: NCT02111395 Recruiting - Autism Clinical Trials

Psychotherapy for Anxiety in Children With Autism Spectrum Disorder

TAASD
Start date: April 2014
Phase: Phase 3
Study type: Interventional

Anxiety disorders affect 40 to 50% of children with autism spectrum disorders (ASD), contributing to substantial distress and impairment. The goal of this study is to examine the effectiveness of a personalized type of psychotherapy against standard-care psychotherapy for addressing anxiety in youth with ASD.

NCT ID: NCT01906268 Recruiting - Clinical trials for Generalized Anxiety Disorder

Attention Retraining for Anxiety Disorder Patients Resistent to Antidepressants

Start date: July 2013
Phase: N/A
Study type: Interventional

The objective of this project is to test the combination of active or placebo Attentional Bias Modification Treatment (ABMT) to usual treatment for anxiety disorder patients resistant to antidepressants.

NCT ID: NCT01815099 Recruiting - Clinical trials for Generalized Anxiety Disorder

Transcranial Magnetic Stimulation Treatment for Generalized Anxiety Disorder

Start date: May 2014
Phase: N/A
Study type: Interventional

We are investigating the feasibility and efficacy of transcranial magnetic stimulation (TMS) for patients with GAD who were placebo nonresponders in DIEF003523.1.

NCT ID: NCT01687764 Recruiting - Clinical trials for Generalized Anxiety Disorder

Combination of Active or Placebo Attentional Bias Modification Treatment (ABMT) to Either Cognitive Behavioral Group Therapy (CBGT) or Psychoeducational Control Intervention (PCI) for Anxiety Disorders in Children

Start date: August 2011
Phase: N/A
Study type: Interventional

The objective of this project is to test the combination of active or placebo Attentional Bias Modification Treatment (ABMT) to either Cognitive Behavioral Group Therapy (CBGT) or Psychoeducational Control Intervention (PCI) for anxiety disorders in children.