Clinical Trials Logo

Clinical Trial Summary

The prognosis for patients with advanced oesophago-gastric cancer is poor. Approximately 16,000 patients in the United Kingdom die from the disease. In spite of new chemotherapy regimens, the average survival for these patients is around 9 months from diagnosis.

Omegaven is an infusion comprising omega-3 fish oils. There is evidence that omega-3 fish oil supplementation can improve general well-being and quality of life in patients receiving palliative chemotherapy for a number of different cancer types. It has also been suggested that omega-3 fish oil supplementation may reduce the toxicity of chemotherapy.

This clinical trial aims to see whether the addition of Omegaven to EOX chemotherapy, the most widely used regimen for patients with advanced oesophago-gastric cancer, will make this drug regimen more effective at killing oesophago-gastric cancer cells, such that disease progression is delayed. Forty-five patients who have been diagnosed with advanced oesophago-gastric cancer will be recruited over a two year period to receive standard chemotherapy and omega-3 fish oil supplementation. The results in these 45 patients will be compared to a matched historical control group of patients who have received identical chemotherapy. If results suggest that the combination of EOX and Omegaven is sufficiently effective, tolerable and feasible then it will be the intention of the trial team to take the combination forward to treat patients with advanced oesophago-gastric cancer in a randomised study.


Clinical Trial Description

n/a


Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT01870791
Study type Interventional
Source University Hospitals, Leicester
Contact
Status Terminated
Phase Phase 2
Start date May 2012
Completion date December 2015

See also
  Status Clinical Trial Phase
Completed NCT02543411 - Use of Lidocaine in Endoscopic Submucosal Dissection N/A
Completed NCT02128243 - Trial of S-1 Maintenance Therapy in Metastatic Esophagogastric Cancer Phase 2
Active, not recruiting NCT00506207 - A Phase I Study of S-1 Plus Irinotecan and Oxaliplatin in Advanced Gastrointestinal Malignancy Phase 1
Completed NCT04830618 - Aberrant DNA Methylation to Predict Metachronous Gastric Neoplasms
Completed NCT02235246 - The Effect of Perioperative Intravenous Magnesium on Pain After Endoscopic Submucosal Dissection for Gastric Neoplasm: Prospective Randomized Double-blind Placebo Controlled Study Phase 4
Completed NCT00252161 - A Trial of Neoadjuvant TS-1 and Cisplatin for Type 4 and Large Type 3 Gastric Cancer Phase 3
Recruiting NCT04622098 - Prevalence of Sub-epithelial Lesions Among Patients Undergoing EGDs in Egypt
Completed NCT03255070 - A Dose-escalation, Expansion Study of ARX788, in Advanced Solid Tumors Subjects With HER2 Expression (ACE-Pan Tumor 01) Phase 1
Recruiting NCT06342427 - Stomach Cancer Exosome-based Detection
Recruiting NCT04780256 - Endoscopic Resection of Gastrointestinal Neoplasms
Recruiting NCT03065257 - Endoscopic Resection Multicenter Registry N/A
Recruiting NCT05804331 - The Australia and New Zealand Multicentre Upper Gastrointestinal Endoscopic Tissue Resection Study
Completed NCT05265221 - Learning Curve for Gastric Endoscopic Submucosal Dissection
Recruiting NCT03597581 - A Study of RGX-202-01 (Ompenaclid) as Combination Therapy in RAS Mutant Advanced Colorectal Cancer Phase 1
Completed NCT00112099 - GCSSG-SPNX: Trial to Evaluate Splenectomy in Total Gastrectomy for Proximal Gastric Carcinoma: JCOG0110 Phase 3
Recruiting NCT04466631 - Health and Employment After Gastro Intestinal Surgery - HEAGIS2
Terminated NCT00149266 - Randomized Controlled Trial to Evaluate Surgical Approaches to Gastric Cancer Invading the Esophagus (JCOG9502) Phase 3
Completed NCT00149279 - A Trial to Evaluate Para-aortic Lymphadenectomy for Gastric Cancer Phase 3
Recruiting NCT06362070 - Comparison of Outcomes of Multiple Platforms for Assisted Robotic - Gastrectomy N/A
Completed NCT01824953 - Long-term Follow-up Prognosis of Atrophic Gastritis After 3 Years N/A