Gallbladder Carcinoma Clinical Trial
Official title:
A Multicentre, Open-label, Randomised, Controlled Study of Target Therapy Based on Tumor Molecular Profiling With GEMOX in Recectable Gallbladder Carcinoma Patients Monitored by ctDNA.
The purpose of this study is to evaluate the feasibility, efficacy and safety of target therapy according to genomic and proteomic profiling combined with GEMOX in recectable gallbladder carcinoma patients monitored by ctDNA.
Status | Recruiting |
Enrollment | 102 |
Est. completion date | December 2023 |
Est. primary completion date | June 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: - Chinese# - Stable vital signs, ECOG:0-1; - Patients have a diagnosis of resectable gallbladder carcinoma by histopathology or cytopathology after radical surgery. - Adequate fresh tumor tissue for genome sequencing and immunohistochemistry test; harboring mutations or abnormal activation of erb-b2 receptor tyrosine kinase signal pathway components - Life expectancy of more than 18 weeks; - T stage= T2 or histopathological lymph node positive according to AJCC (8th edition) staging. - Adequate hepatic, hematologic and renal functions(ALT=5×upper limit of normal (ULN), AST=5×ULN, the Child-Pugh classification for class A or B, white blood cells=3×10^9/L, neutrophils=1.5×10^9/L, platelets=75×10^9/L , hemoglobin = 90g/L, creatinine clearance rate=60ml/min; - Volunteer for this study, have written informed consent and have good Patient compliance; - Female patients of childbearing potential and their mates agree to avoid pregnancy. Exclusion Criteria: - Have received following treatment before this study: a. Anti-tumor molecular target therapy; anti-tumor chemotherapy in 6 months; b. lesions have been treated by irradiation; c. participate in other therapeutic or interventional clinical trials. - History of other malignancies except carcinoma in-situ of uterine cervix, cured basal cell carcinoma of skin and other malignancies for more than 5 years; - Have serious concurrent illness including, but not limited to uncontrolled congestive heart failure(NYHA classification grade III or IV), unstable angina pectoris, unstable cardiac arrhythmias, uncontrolled moderate or serious hypertension(systolic blood pressure >21.3 Kpa or diastolic blood pressure >13.3 Kpa); - Have ongoing or active serious infection; - Have uncontrolled diabetes mellitus; - Psychiatric illness which potentially hamper the ability to willingly give written informed consent and compliance with the study protocol; - Active autoimmune diseases require long-term use of steroids or received allotransplantation - Other serious illness considered not suitable for this study by investigators. |
Country | Name | City | State |
---|---|---|---|
China | Renji hospital, Shanghai Jiaotong University School of Medicine | Shanghai | Shanghai |
China | Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine | Shanghai | Shanghai |
Lead Sponsor | Collaborator |
---|---|
Shanghai Jiao Tong University School of Medicine | RenJi Hospital, Ruijin Hospital, Shanghai Zhongshan Hospital |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | sensitivity and specificity of ctDNA | sensitivity and specificity of ctDNA compared to clinical index(CA199,CEA)for monitoring tumour progression | up to 2 years | |
Primary | 3-year DFS | 3-year disease free survival rates:The progression is defined consistent with contrast enhanced MRI/CT. | up to 3 years | |
Secondary | 3-year OS | 3-year Overall survival rates | up to 3 years |
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT05009953 -
Study of Irinotecan Liposome Injection in Patients With Advanced Biliary Tract Cancer
|
Phase 2 | |
Recruiting |
NCT05285358 -
Pressurized Intraperitoneal Aerosolized Nab-Paclitaxel in Combination With Gemcitabine and Cisplatin for the Treatment of Biliary Tract Cancer Patients With Peritoneal Metastases
|
Phase 1 | |
Recruiting |
NCT04430738 -
Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers
|
Phase 1/Phase 2 | |
Active, not recruiting |
NCT04853017 -
A Study of ELI-002 in Subjects With KRAS Mutated Pancreatic Ductal Adenocarcinoma (PDAC) and Other Solid Tumors
|
Phase 1 | |
Active, not recruiting |
NCT05222854 -
Comprehensive Genomic Profiling Combined With Real Life Data of "The German-Registry of Incidental Gallbladder Carcinoma"
|
||
Not yet recruiting |
NCT05681949 -
Therapeutic Assistance and Decision-making Algorithms in Hepatobiliary Tumor Boards
|
N/A | |
Active, not recruiting |
NCT02151084 -
A Study of Different Dosing Schedules of Selumetinib With Cisplatin/Gemcitabine (CIS/GEM) Versus CIS/GEM Alone in Biliary Cancer
|
Phase 2 | |
Terminated |
NCT01855724 -
Clinical Trial to Investigate the Efficacy of Treatment With Gemcitabine/Pazopanib in Patients With Biliary Tree Cancer
|
Phase 2 | |
Withdrawn |
NCT02105350 -
A Study of MEK162 With Gemcitabine and Oxaliplatin in Biliary Cancer
|
Phase 1 | |
Active, not recruiting |
NCT02834013 -
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors
|
Phase 2 | |
Completed |
NCT02649712 -
Unilateral Stenting Versus Bilateral Stenting for Malignant Hilar Biliary Obstruction
|
N/A | |
Recruiting |
NCT05194072 -
A Study of SGN-B7H4V in Advanced Solid Tumors
|
Phase 1 | |
Recruiting |
NCT03581435 -
A Study of Circulating Exosome Proteomics In Gallbladder Carcinoma Patients
|
||
Completed |
NCT03201458 -
Atezolizumab With or Without Cobimetinib in Treating Patients With Metastatic Bile Duct Cancer That Cannot Be Removed by Surgery or Gallbladder Cancer
|
Phase 2 | |
Completed |
NCT04740164 -
A Dual Channel Supraglottic Airway Device (LMA Gastro) for Oxygenation in Patients Undergoing ERCP
|
N/A | |
Completed |
NCT02333188 -
Genetic Analysis-Guided Dosing of FOLFIRABRAX in Treating Patients With Advanced Gastrointestinal Cancer
|
Phase 1 | |
Recruiting |
NCT05712356 -
A Study of LSTA1 When Added to Standard of Care Versus Standard of Care Alone in Patients With Advanced Solid Tumors
|
Phase 2 | |
Terminated |
NCT00767234 -
Permission to Collect Blood Over Time for Research
|
N/A | |
Recruiting |
NCT03702491 -
Apapitatin Combined With SOX for Palliative Adjuvant Chemotherapy in Patients With Advanced Gallbladder Carcinoma
|
Phase 2 | |
Recruiting |
NCT04068194 -
Testing the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies
|
Phase 1/Phase 2 |