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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT04183712
Other study ID # LTGBCLYB2019
Secondary ID
Status Recruiting
Phase Phase 2
First received
Last updated
Start date June 1, 2020
Est. completion date December 2023

Study information

Verified date December 2022
Source Shanghai Jiao Tong University School of Medicine
Contact Yingbin Liu, PHD
Phone +8613918803900
Email laoniulyb@163.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of this study is to evaluate the feasibility, efficacy and safety of target therapy according to genomic and proteomic profiling combined with GEMOX in recectable gallbladder carcinoma patients monitored by ctDNA.


Description:

Genomic profiling studies the deoxyribonucleic acid (DNA) of a tumor to detect genetic changes or abnormalities. immuno-histochemistry tests reveal the abnormal activation status of signal pathways involved in study. These information will be used to recommend target therapy which may be more likely to result in a beneficial response. Patients will receive target antitumor agents according to the result of genomic and proteomic profiling and be monitored by circulating tumor DNA(ctDNA).


Recruitment information / eligibility

Status Recruiting
Enrollment 102
Est. completion date December 2023
Est. primary completion date June 2023
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: - Chinese# - Stable vital signs, ECOG:0-1; - Patients have a diagnosis of resectable gallbladder carcinoma by histopathology or cytopathology after radical surgery. - Adequate fresh tumor tissue for genome sequencing and immunohistochemistry test; harboring mutations or abnormal activation of erb-b2 receptor tyrosine kinase signal pathway components - Life expectancy of more than 18 weeks; - T stage= T2 or histopathological lymph node positive according to AJCC (8th edition) staging. - Adequate hepatic, hematologic and renal functions(ALT=5×upper limit of normal (ULN), AST=5×ULN, the Child-Pugh classification for class A or B, white blood cells=3×10^9/L, neutrophils=1.5×10^9/L, platelets=75×10^9/L , hemoglobin = 90g/L, creatinine clearance rate=60ml/min; - Volunteer for this study, have written informed consent and have good Patient compliance; - Female patients of childbearing potential and their mates agree to avoid pregnancy. Exclusion Criteria: - Have received following treatment before this study: a. Anti-tumor molecular target therapy; anti-tumor chemotherapy in 6 months; b. lesions have been treated by irradiation; c. participate in other therapeutic or interventional clinical trials. - History of other malignancies except carcinoma in-situ of uterine cervix, cured basal cell carcinoma of skin and other malignancies for more than 5 years; - Have serious concurrent illness including, but not limited to uncontrolled congestive heart failure(NYHA classification grade III or IV), unstable angina pectoris, unstable cardiac arrhythmias, uncontrolled moderate or serious hypertension(systolic blood pressure >21.3 Kpa or diastolic blood pressure >13.3 Kpa); - Have ongoing or active serious infection; - Have uncontrolled diabetes mellitus; - Psychiatric illness which potentially hamper the ability to willingly give written informed consent and compliance with the study protocol; - Active autoimmune diseases require long-term use of steroids or received allotransplantation - Other serious illness considered not suitable for this study by investigators.

Study Design


Related Conditions & MeSH terms


Intervention

Drug:
gemcitabine and oxaliplatin.
GEMOX Conventional chemotherapy:gemcitabine and oxaliplatin.
Afatinib
Target therapy Drug: afatinib

Locations

Country Name City State
China Renji hospital, Shanghai Jiaotong University School of Medicine Shanghai Shanghai
China Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Shanghai

Sponsors (4)

Lead Sponsor Collaborator
Shanghai Jiao Tong University School of Medicine RenJi Hospital, Ruijin Hospital, Shanghai Zhongshan Hospital

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Other sensitivity and specificity of ctDNA sensitivity and specificity of ctDNA compared to clinical index(CA199,CEA)for monitoring tumour progression up to 2 years
Primary 3-year DFS 3-year disease free survival rates:The progression is defined consistent with contrast enhanced MRI/CT. up to 3 years
Secondary 3-year OS 3-year Overall survival rates up to 3 years
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