Hepatocellular Carcinoma Clinical Trial
Official title:
Unilateral Stenting Versus Bilateral Stenting for Malignant Hilar Biliary Obstruction
The purpose of this study is to compare the clinical effectiveness and long-term outcomes between patients with malignant hilar biliary obstruction who are treated by unilateral or bilateral stenting.
Malignant hilar biliary obstruction is a common clinical manifestation and it can be caused
by cholangiocarcinoma, gallbladder carcinoma, liver cancer, or other metastatic carcinoma.
Most patients with malignant hilar biliary obstruction are unresectable at diagnosis. Biliary
stenting has been widely used in palliative treatment of malignant hilar biliary obstruction.
Hilar biliary obstruction usually involves the bifurcation of the biliary tract. Some
researchers recommended unilateral stenting for malignant hilar biliary obstruction because
drainage of 25% of entire liver can achieve the clinical success of biliary drainage.
However, some researchers recommended bilateral stenting for malignant hilar biliary
obstruction because some researches demonstrated that bilateral stenting can achieve a longer
stent patency.In addition, there was no significant difference in post stenting survival
between patients who were treated by unilateral or bilateral stenting. Therefore, it remains
under debate whether unilateral or bilateral stenting is better in the treatment of malignant
hilar biliary obstruction.
The purpose of this study is to compare the clinical effectiveness and long-term outcomes
between patients with malignant hilar biliary obstruction who are treated by unilateral or
bilateral stenting.
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