Heart Failure Clinical Trial
Official title:
A Small-Scale Study to Explore the Safety and Feasibility of Allogeneic Young Plasma Infusion in Older Adults Experiencing Disability Across the Spectrum of Frailty Syndrome
Evaluate the feasibility of administering plasma (PF24) acquired from donors of a young chronological age intravenously to older adults at WFBMC while also exploring its effects on age-related functional decline
A Small-Scale Study to Explore the Safety and Feasibility of Allogeneic Young Plasma Infusion
in Older Adults Experiencing Disability Across the Spectrum of Frailty Syndrome
Plasma (PF24) will be transfused into enrolled male and female geriatric patients aged 65-80
who have a diagnosis of frailty (Fried Frailty score of 3 or greater) or HFpEF. The
experimental dosing will consist of once weekly administration of PF24 over a period of 8
consecutive weeks (8 total doses over 56 days). Primary and secondary endpoints will measure
safety and feasibility of infusing PF24 in this study population. Tertiary endpoints will
include measurement of the Fried Frailty score, various cognitive testing, measurement of
VO2max, and blood biomarkers associated with aging. We will measure change from baseline 1
week after the 8th infusion of PF24. Test of durability will occur 5 weeks after the 8th
infusion of plasma.
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