Fluid Overload and Hypertension in Hemodialysis Patients Clinical Trial
Official title:
Effect of Sodium Concentration of Priming and Rinsing Fluids on Interdialytic Weight Gain and Blood Pressure in Hemodialysis Patients: a Prospective Pilot Study
Sodium loading during hemodialysis treatment is common and may contribute to increased
interdialytic weight gain and hypertension. Excessive use of isotonic saline (containing
0.9% sodium chloride) is one of the factors that may cause sodium loading. During each
hemodialysis session, approximately 400 mL of isotonic saline fluid, representing 1.4 grams
of sodium, is used to prime and rinse the extracorporeal circuit, and is often administered
to the patient. Switching to a non sodium-containing priming and rinsing fluid could allow
for removal of the equivalent amount of sodium.
Switching to a non sodium-containing solution for the priming and rinsing of the
extracorporeal circuit can contribute to increased sodium removal during the dialysis
treatment and allow for reduced interdialytic weight gain, reduced thirst, and improved
blood pressure control.
This 12 week study consists of 3 phases:
Phase 1 (4 weeks): Observation only. Standard priming/rinsing procedure with isotonic saline
Phase 2 (4 weeks): Intervention. Switch to a 5% dextrose solution for priming/rinsing
procedure Phase 3 (4 weeks): Switch back to standard priming/rinsing procedure with isotonic
saline During the study, blood pressures will be measured in a standardized manner at 2 week
intervals, a thirst questionnaire will be completed at the end of each phase, and
interdialytic weight gain, in-center pre/post-HD blood pressure and intradialytic symptoms
will be recorded, apart for routinely measured parameters.
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