Etiology of Uncomplicated Fever in Children <5 in Rural Zanzibar — RDTNEG  

Fever Clinical Trial

Official title: Infectious Disease Etiologies of Uncomplicated Febrile Illness in Children <5 Years of Age in Rural Zanzibar

Status Completed

Clinical Trial Summary

The purpose of this study is to study the most common etiologies of uncomplicated fever diseases among children under five years of age in rural Zanzibar.

Clinical Trial Description

During the last 6 years Zanzibar has undergone a dramatic change in malaria epidemiology and burden of disease, with a marked decline of Plasmodium falciparum malaria among febrile children from approximately 30% to 1% or below and a reduction of crude child mortality of 50%. Millions of children in Africa die of neonatal disorders, acute respiratory tract infections (ARI), diarrhea, malaria, measles, HIV and malnutrition. A majority of these illnesses are also a common cause of febrile illness in out-patient departments. However, most of the few fever studies made in Africa are hospital based Very few studies on etiology of childhood febrile disease have been conducted on first level health facilities in the least developed countries in Africa. This study will therefore focus on children between 2 months to 5 years of age that have been diagnosed with a negative rapid diagnostic test (RDT) for malaria and their causes of fever at the first referral level in out-patient clinics in Zanzibar. ;

Study Design

Observational Model: Cohort

Related Conditions & MeSH terms

• Communicable Diseases
• Fever
• Infection
• Infectious Disease

• NCT number: NCT01094431
• Study type: Observational
• Source: Karolinska University Hospital
• Status: Completed
• Phase: N/A
• Start date: April 2011
• Completion date: July 2011