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Fertilization in Vitro clinical trials

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NCT ID: NCT04124913 Recruiting - Infertility, Female Clinical Trials

Oral Dydrogesterone vs. Micronized Vaginal Progesterone for Luteal Phase Support in Frozen-thawed Embryo Transfer Cycles

Start date: January 2, 2019
Phase: Phase 4
Study type: Interventional

The aim of this randomized controlled trial is to compare the efficacy of oral dydrogesterone vs. micronized vaginal progesterone for luteal phase support in frozen-thawed embryo transfer cycles.

NCT ID: NCT03733912 Completed - Clinical trials for Fertilization in Vitro

Plasticizers and in Vitro Fertilization Outcomes

Start date: July 11, 2018
Phase:
Study type: Observational

To investigate the effect of Plasticizer metabolites concentration on the in vitro fertilization outcomes

NCT ID: NCT03713723 Recruiting - Clinical trials for Fertilization in Vitro

Cardiac Output Monitoring in IVF Patients

Start date: June 1, 2017
Phase:
Study type: Observational

In this study we aim to evaluate hemodynamic effects of IVF treatment, with the use of the non invasive NICaS bioimpendence monitor. Our study's primary end point is to evaluate the hemodynamic profile with the use of NICaS whole body impedance cardiography that occur throughout the IVF cycle in patients undergoing controlled ovarian stimulation during IVF treatment. Secondary endpoints include: Women will be asked to grade their pain score and level of anxiety by the use of the visual analogue score elicited throughout the study observation points, in order to examine whether pain scores and anxiety levels correlate with the hemodynamic changes throughout an IVF treatment cycle.

NCT ID: NCT03700255 Recruiting - Infertility Clinical Trials

Efficacy of a Simulator Based (PickUpSimTM) Residents' Training Program for Oocyte Retrievals

Start date: May 1, 2018
Phase: N/A
Study type: Interventional

Simulation is an educational approach that has recently found an application in healthcare.acquire. Angers university hospital has decided to acquire, in December 2016, the high-fidelity Oocyte Pick up (OPU) simulator PickUpSimTM, and the investigators have put in place a training novel program containing different simulation based courses. It is essential to analyze its impact on the clinical practice before implementing it on a larger scale. Initial hypothesis was that the residents' lack of specific training and inexperience would result in suboptimal oocyte retrievals, especially for their first cases The investigators will undertake a prospective comparative study at the In Vitro Fertilization (IVF) unit of the Angers University Hospital between May 2019 and April 2022. The investigators will include all voluntary residents in rotation at the IVF unit in that time period. The participants will be divided in two groups: Group A will undergo the PickUpSimTM simulation training program whereas group B will only have the classic training with no simulation. The primary objective is to assess the benefits of an OPU simulation training program using the PickUpSimTM simulator for teaching residents in a university-affiliated IVF center. The main criterion the investigators will use is the "oocyte retrieval rate" (ORR) during the first month following 15 days of simulation training. The ORR is calculated as the number of oocytes retrieved divided by the number of follicles aspirated. Our secondary objectives are: - To assess the residents' satisfaction with the simulation training program. - To evaluate the learning curve of residents during the two weeks of training. - To compare the OPU complication rate between residents with and without previous simulation training. - To analyze the oocyte retrieval rate in the second and third month of REI rotation for residents, and compare it between those with and those without simulation training.

NCT ID: NCT03527823 Completed - Clinical trials for Fertilization in Vitro

The Comparison of Granulosa Cell Apoptosis Rates With or Without Luteinizing Hormone Administration in Poor Responders.

Start date: October 17, 2018
Phase:
Study type: Observational [Patient Registry]

In Zeynep Kamil Women and Children's Education and Research Hospital which is a tertiary referral hospital, the investigators perform microdose flare-up gonadotropin-releasing hormone (GNRH) analogue or GNRH antagonist protocol to the poor responders. The investigators may or may not supplement luteinizing hormone (LH). Human chorionic gonadotropin (hCG) triggering is performed when at least 2 follicles diameter are above 17 mm and the serum estradiol level is above 500 pg / ml. 36 hours after hCG, ovarian aspiration is performed by the guidance of transvaginal ultrasound. Normally after oocyte separation process, the remaining follicle aspiration fluid is destroyed. n the present study, the follicle aspiration fluid is planned to be used with the patient's permission. The investigators are going to examine the granulosa cell apoptosis rate by using annexin-5 antibody in both groups 1 (LH added) and 2 (without LH). For this purpose, a total of 40 volunteer patients are planned to involve, the groups are designed as 20 LH added and 20 LH added women. In the present study, the investigators hypothesis that the rates of granulosa cell apoptosis in poor responders may be different between the group 1 (with LH) and group 2 (without LH), this will lead to IVF therapy in the near future.

NCT ID: NCT03238833 Completed - Clinical trials for Fertilization in Vitro

Poor Ovarian Responders Undergoing IVF Using Luteal Ovarian Stimulation Versus Follicular Ovarian Stimulation

Start date: May 3, 2017
Phase: N/A
Study type: Interventional

The investigators attempted to compare the clinical outcomes and cumulus genes expression in poor ovarian responders undergoing luteal ovarian stimulation or follicular ovarian stimulation in in vitro fertilization cycles.

NCT ID: NCT03201783 Completed - Embryo Transfer Clinical Trials

Immediate Versus Delayed FET Following a Stimulated IVF Cycle

Start date: August 9, 2017
Phase: N/A
Study type: Interventional

Information regarding the optimal timing for frozen-thawed embryo transfer (FET) following a stimulated in vitro fertilization (IVF) is lacking. One option is to perform FET in the first cycle following the stimulated IVF cycle, i.e. immediate transfer. Another option is to postpone FET for at least one menstrual cycle, i.e. delayed transfer. This randomized study aims to compare the ongoing pregnancy rate of immediate versus delayed FET following a stimulated IVF cycle.

NCT ID: NCT03062098 Withdrawn - Clinical trials for Fertilization in Vitro

Optimizing the Technique of Embryo Transfer in IVF Using Better Imaging Guidance

Start date: May 15, 2017
Phase: N/A
Study type: Interventional

This trial seeks to improve ultrasound imaging during embryo transfer in IVF by using a small, high resolution ultrasound probe used routinely for cardiac imaging in children.

NCT ID: NCT02990949 Terminated - Infertility Clinical Trials

The Impact of the Timing of Trigger on IVF Success

Start date: November 2016
Phase: N/A
Study type: Interventional

The aim of this study is to examine the length of ovarian stimulation with the timing of trigger in an IVF cycle and its potential to impact patient outcomes.

NCT ID: NCT02971280 Not yet recruiting - Clinical trials for Fertilization in Vitro

Influence of Heavy Metals Exposure on in Vitro Fertilization (IVF) Outcome

Start date: November 2016
Phase: N/A
Study type: Observational

Exposure to heavy metals may interfere with basic cellular functions, including DNA synthesis. The aim of the study is to correlate heavy metals concentration in body fluids of reproductive importance and IVF outcome.