Female, Late Life Depression Clinical Trial
Official title:
Central Glutathione Levels in Women With Late Life Depression: a Cross Sectional Pilot Feasibility Study
Female participants with an episode of late-life depression (LLD) and age-matched control participants with no history of mental disorder will attend a one hour Magnetic Resonance Imaging (MRI). A 3 Tesla MRI scanner will be used to measure levels of glutathione (GSH) in the brain via magnetic resonance spectroscopy (1H MRS).
This is a pilot/feasibility, single-centre, open-label, cross-sectional study. Research
participants will be women aged 60 to 85. This study seeks to recruit 26 female participants;
13 participants with a confirmed diagnosis of late-life depression and 13 control
participants with no history of mental illness. This pilot study will be used to determine if
a larger Randomized Controlled Trial is feasible.
The role of antioxidant capacity in Late Life Depression (LLD) has thus far been inadequately
assessed, providing the investigators with a timely opportunity to spearhead such an
investigation. The results of this pilot study, and subsequent large-scale studies, will
allow the investigators to identify novel targets for therapeutic intervention in LLD.
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