AROPE : Early Ovarian Reserve Decreased : Impact of Exposure to Persistent

Status Completed

Clinical Trial Summary

Early ovarian reserve decreased is one of the main causes of infertility for women after 35 years. The relationship between this decreased and exposure to chemicals, including persistent endocrine disruptors or organic solvents, has been little studied. However, several in vivo or in vitro experimental studies suggested that these chemicals may impaired ovarian function. The main objective is to study the relationship between early ovarian reserve decreased and exposure to persistent organic pollutants. The secondary objectives are to study the relationship between early ovarian reserve decreased and exposure to organic solvents and heavy metals. Multicenter case-control study. This project will permit to increase the knowledge concerning the etiology of early decreased ovarian reserve. Considering that exposure of interest are frequent, the results may be important in a public health perspective. If associations are observed in this study, the results may encouraged prevention strategy.

Clinical Trial Description

Cases and controls will benefit, as usual in France concerning infertility etiology examinations, of a follicle antral count by transvaginal ultrasound and AMH measurement. At baseline, physicians will complete a short questionnaire to check the inclusion criterion, the results of the measurement of follicle count and hormone measurement (including AMH). Cases and controls will respond to self-administered questionnaire at inclusion with information about their medical history, their demographics, their tobacco and alcohol consumption, their occupation and products handled in the workplace. Blood samples (for measure of persistent organic pollutants and heavy metals) and urine (for measure of metabolites of glycol ethers) will be collect at baseline. Occupational exposures to solvents will be defined using job exposures matrices. The risk of decreased ovarian reserve will be analyzed using logistic regressions for each exposure of interest adjusting for potential confounders. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02802397
Study type	Interventional
Source	Rennes University Hospital
Contact
Status	Completed
Phase	N/A
Start date	December 6, 2016
Completion date	November 2, 2020

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT06239051` - Greening the Humanitas Fertility Center: How to Build a More Sustainable Medical Daily Routine
Recruiting	`NCT05179993` - Detection of Microplastics in Human Granulosa Cells and in the Follicular Fluid of Women Undergoing ICSI Treatment
Recruiting	`NCT03767569` - Myo-inositol as Pretreatment in Hyperandrogenic PCOS Patients	Phase 3
Completed	`NCT03737253` - Hormone Evaluation in Artificial Reproductive Technology	Phase 4
Not yet recruiting	`NCT02237781` - Levels of Anti-Mullerian Hormone (AMH) During Ovarian Stimulation With Gonadotropins	Phase 2/Phase 3
Not yet recruiting	`NCT02237755` - Clomiphene Citrate in Combination With Gonadotropins for Ovarian Stimulation in Women With Poor Ovarian Response.	Phase 2/Phase 3
Completed	`NCT01477073` - Multiple Dose FSH-GEX(TM) in Healthy Volunteers	Phase 1
Recruiting	`NCT00119925` - 'SPRING'-Study: "Subfertility Guidelines: Patient Related Implementation in the Netherlands Among Gynaecologists"	N/A
Recruiting	`NCT06098495` - Looking for a Blood Epigenetic Signature to Predict Female Infertility
Completed	`NCT03998553` - Study for Obtaining Mature Oocytes by in Vitro Maturation in Oocyte-donor Women	N/A
Completed	`NCT05189145` - Hormonal Monitoring and Progesterone Adjustment in Frozen Embryo Transfer Cycles	N/A
Recruiting	`NCT05050747` - Study to Assess the Effect of Intrauterine Adminstration of HCG Versus Endometrial Injury by Pipelle
Completed	`NCT01620346` - Intracytoplasmic Morphologically Selected Sperm Injection and Advanced Maternal Age	N/A
Completed	`NCT00315029` - Patient-Centered Implementation Trial for Single Embryo Transfer	N/A
Recruiting	`NCT03080584` - Effect of 12 Weeks of Acupuncture on AMH and COH in Low Responder Patients	N/A
Not yet recruiting	`NCT05106712` - Vitamin D Supplementation and Improvement of PCOS Therapy and IVF Outcomes in Infertile Saudi Women	N/A
Recruiting	`NCT06041204` - Best Treatment for Women With Both (Polycystic Ovary Syndrome) PCOS and Subclinical Hypothyroidism	N/A
Completed	`NCT02328924` - There is a Value of Luteinizing Hormone Predictive of in Vitro Fertilization Treatment Outcome in Antagonist Protocols?	Phase 4
Completed	`NCT01604044` - Highly Purified Menotropin (HP-hMG) Versus Recombinant FSH (rFSH) Plus Recombinant LH (rLH) in Intrauterine Insemination Cycles in Women ≥35 Years: a Prospective Randomized Trial.	Phase 1
Completed	`NCT04019899` - Myo-inositol and Vitamin D3 During IVF	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

AROPE : Early Ovarian Reserve Decreased : Impact of Exposure to Persistent Endocrine Disruptors and Organic Solvents — AROPE

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms