Female Infertility Clinical Trial
Official title:
Prospective Randomized Phase IV Study Comparing the Effect of Adding Clomiphencitrate Versus Placebo to a High Dose Versus a Minimal Dose GnRH Antagonist Protocol on the Number of Oocytes Collected From Women That Are Poor Responders
The aim of this study is to assess the oocyte yield of infertile women with suspected or known poor ovarian reserve (POR) undergoing a GnRH antagonist protocol for IVF with Merional® starting either with a low (150 IU) or a high dose (450 IU) and adding 100mg of CC (Serophene®) in the early follicular phase of the stimulation (day 3 to 7). To date no RCT has been conducted to compare the reproductive outcome of patients with POR as defined by the ESHRE Bologna criteria after controlled ovarian hyperstimulation with HMG in an GnRH antagonist protocol using low doses versus high doses of HMG and adding CC versus placebo. We hypothesize that adding 100 mg of CC on day 3-7 to a HMG antagonist protocol will lead to an additional increment of endogenous GT thus increasing the oocytes yield after controlled ovarian stimulation due to higher endogenous gonadotropin secretion.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT06239051 -
Greening the Humanitas Fertility Center: How to Build a More Sustainable Medical Daily Routine
|
||
| Recruiting |
NCT05179993 -
Detection of Microplastics in Human Granulosa Cells and in the Follicular Fluid of Women Undergoing ICSI Treatment
|
||
| Recruiting |
NCT03767569 -
Myo-inositol as Pretreatment in Hyperandrogenic PCOS Patients
|
Phase 3 | |
| Completed |
NCT03737253 -
Hormone Evaluation in Artificial Reproductive Technology
|
Phase 4 | |
| Not yet recruiting |
NCT02237755 -
Clomiphene Citrate in Combination With Gonadotropins for Ovarian Stimulation in Women With Poor Ovarian Response.
|
Phase 2/Phase 3 | |
| Not yet recruiting |
NCT02237781 -
Levels of Anti-Mullerian Hormone (AMH) During Ovarian Stimulation With Gonadotropins
|
Phase 2/Phase 3 | |
| Completed |
NCT01477073 -
Multiple Dose FSH-GEX(TM) in Healthy Volunteers
|
Phase 1 | |
| Recruiting |
NCT00119925 -
'SPRING'-Study: "Subfertility Guidelines: Patient Related Implementation in the Netherlands Among Gynaecologists"
|
N/A | |
| Recruiting |
NCT06098495 -
Looking for a Blood Epigenetic Signature to Predict Female Infertility
|
||
| Completed |
NCT03998553 -
Study for Obtaining Mature Oocytes by in Vitro Maturation in Oocyte-donor Women
|
N/A | |
| Completed |
NCT05189145 -
Hormonal Monitoring and Progesterone Adjustment in Frozen Embryo Transfer Cycles
|
N/A | |
| Recruiting |
NCT05050747 -
Study to Assess the Effect of Intrauterine Adminstration of HCG Versus Endometrial Injury by Pipelle
|
||
| Completed |
NCT01620346 -
Intracytoplasmic Morphologically Selected Sperm Injection and Advanced Maternal Age
|
N/A | |
| Completed |
NCT00315029 -
Patient-Centered Implementation Trial for Single Embryo Transfer
|
N/A | |
| Recruiting |
NCT03080584 -
Effect of 12 Weeks of Acupuncture on AMH and COH in Low Responder Patients
|
N/A | |
| Not yet recruiting |
NCT05106712 -
Vitamin D Supplementation and Improvement of PCOS Therapy and IVF Outcomes in Infertile Saudi Women
|
N/A | |
| Recruiting |
NCT06041204 -
Best Treatment for Women With Both (Polycystic Ovary Syndrome) PCOS and Subclinical Hypothyroidism
|
N/A | |
| Completed |
NCT02328924 -
There is a Value of Luteinizing Hormone Predictive of in Vitro Fertilization Treatment Outcome in Antagonist Protocols?
|
Phase 4 | |
| Completed |
NCT01604044 -
Highly Purified Menotropin (HP-hMG) Versus Recombinant FSH (rFSH) Plus Recombinant LH (rLH) in Intrauterine Insemination Cycles in Women ≥35 Years: a Prospective Randomized Trial.
|
Phase 1 | |
| Completed |
NCT04019899 -
Myo-inositol and Vitamin D3 During IVF
|
N/A |