Feeding Behavior Clinical Trial
Official title:
Comparison of Time-restricted Feeding and Continuous Feeding in Critically Ill Patients
In the nutrition guideline (A.S.P.E.N guideline), there was no recommendation about the
feeding type in enteral feeding of critically ill patients. Continuous feeding is the most
popular feeding type in ICU because of its less nursing burden and reducing the aspiration
incidence theoretically. However, some previous studies demonstrated that there were no
complications differences between continuous and time-restricted feedings（such as
intermittent feedings）.
In ICU, the disorder of protein synthesis is a universal problem and is associated with ICU
acquired weakness. Time-restricted feeding is more physical than continuous feeding. In some
animal researches, time-restricted feeding was proved to have a greater stimulatory effect on
protein synthesis than continuous feeding. Besides of light, time-restricted feeding can may
also adjust the biological rhythms. It is known that biological clocks could affect energy
metabolism, emotion and so on. Until now, there are no enough clinical studies to prove the
advantages in time-restricted feeding in ICU patients.So researchers designed the study to
compare the time-restricted feeding and continuous feeding effect(especially protein
synthesis) on ICU patients.
Enteral nutrition support can be administered by continuous administration or by
time-restricted administration in ICU. Continuous feeding is the most popular feeding
schedule because of its less nursing burden and reducing the aspiration prevalence
theoretically. However, previous studies demonstrated that there was no complications
(diarrhea, distension, Ventilator associated pneumonia-VAP incidence, and so on) difference
between these two feeding schedule. So in the nutrition guideline (A.S.P.E.N guideline),
there was no recommendation about the feeding schedule. However, time-restricted feeding is
more physical than continuous feeding. In ICU, the disorder of protein synthesis is a
universal problem and is associated with ICU acquired weakness. In some animal researches,
time-restricted feeding was proved to have a greater stimulatory effect on protein synthesis
than continuous feeding.
Besides of light, time-restricted feeding can adjust the biological rhythms. It is known that
biological clocks could affect energy metabolism, emotion and so on. In the "zi wu liu zhu"
theory of traditional chinese medicine, feeding time should be at 7:00-9:00, 11:00-13:00 and
17:00-19:00. So researchers designed the study to compare the time-restricted feeding
according to traditional chinese medicine and continuous feeding effect(especially protein
synthesis) on ICU patients.
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