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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT05464342
Other study ID # EEBK/E?/2018/10
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date July 5, 2022
Est. completion date May 31, 2023

Study information

Verified date June 2023
Source University of Thessaly
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of this study is to examine the effect of long-term carbohydrate periodization protocols on sleep architecture, sleep quality, daytime sleepiness, physical performance, body composition, gut microbiome, and miRNA in healthy trained individuals.


Description:

Athletic populations have been particularly susceptible to sleep inadequacies, experience several sleep issues, and fall below the age-specific sleep recommendations. However, it is well demonstrated that exercise does not impair sleep by itself, and furthermore, acute post-exercise nutrition could elevate the exercise-induced sleep-optimizing effect, with further benefits for the next physical performance. In line with these findings, in a metanalysis of clinical trials, it was shown that pre-bed carbohydrate availability resulted in significant alterations in sleep architecture. It is of utmost importance to highlight that throughout this metanalysis, it was revealed that no long-term nutrition intervention for sleep optimization has been studied yet. These data raise the question of whether a long-term carbohydrate periodization protocol could optimize sleep and alter gut function in a way that athletic performance will be also enhanced. This would allow elucidating further potential interrelations and biological pathways underlying these adaptations.


Recruitment information / eligibility

Status Completed
Enrollment 45
Est. completion date May 31, 2023
Est. primary completion date April 1, 2023
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 18 Years to 50 Years
Eligibility Inclusion Criteria: - Both sexes, Age between 18 and 50 yrs old, Regularly participating in sports activities. Exclusion Criteria: - Any kind of history of major diseases or medication, Excessive amounts of alcohol and caffeine consumption

Study Design


Related Conditions & MeSH terms


Intervention

Behavioral:
Evening LGI Carbohydrate Consumption Group
Participants will receive in the evening food with low glycemic index
Evening HGI Carbohydrate Consumption
Participants will receive in the evening food with high glycemic index
Evening NO-CHO Carbohydrate Consumption
Participants will receive in the evening a meal with no carbohydrates at all.

Locations

Country Name City State
Cyprus Department of Life and Health Sciences Nicosia
Greece Lifestlye Medicine Laboratory, TEFAA, University of Thessaly Trikala Thessaly

Sponsors (3)

Lead Sponsor Collaborator
University of Thessaly University of Cyprus, University of Nicosia

Countries where clinical trial is conducted

Cyprus,  Greece, 

Outcome

Type Measure Description Time frame Safety issue
Primary Sleep Efficiency Changes sleep efficiency assessed by the gold-standard method of polysomnography. Sleep efficiency is the percentage of time spent asleep while in bed. It is calculated by dividing the amount of time spent asleep (in minutes) by the total amount of time in bed (in minutes). A normal sleep efficiency is considered to be 85% or higher. Assessed at 0-month (pre) and at 1-month (post)
Primary Quality of Sleep Score Changes in Quality of Sleep will be assessed by the Pittsburgh Sleep Quality Index. The Pittsburgh Sleep Quality Index (PSQI) is a self-report questionnaire that assesses sleep quality over a 1-month time interval. The measure consists of 19 individual items, creating 7 components that produce one global score. The sleep component scores are summed to yield a total score ranging from 0 to 21 with the higher total score (referred to as the global score) indicating worse sleep quality. Assessed at 0-month (pre) and at 1-month (post)
Primary Daytime Sleepiness Changes in Daytime sleepiness will be assessed by Epworth Sleepiness Scale (ESS). The Epworth Sleepiness Scale (ESS) measures the general level of daytime sleepiness. It is a subjective scale that asks the respondent to rate his or her propensity to doze or fall asleep during 8 common daily activities to determine the level of daytime sleepiness. The score varies between 0-24 with 0-5 Lower Normal Daytime Sleepiness, 6-10 Higher Normal Daytime Sleepiness, 11-12 Mild Excessive Daytime Sleepiness, 13-15 Moderate Excessive Daytime Sleepiness, 16-24 Severe Excessive Daytime Sleepiness. Assessed at 0-month (pre) and at 1-month (post)
Secondary Body Composition Changes in Body composition. The changes in body composition will be assessed by the skinfold measurements and BIA Assessed at 0-month (pre) and at 1-month (post)
Secondary Exercise Performance Changes in Exercise Performance will be assessed by a VO2max test. A VO2 max test is a maximal exercise test performed on a treadmill or bike while connected to a machine capable of analyzing your expired air. Your test provides data on how much oxygen you use as you exercise and determines the maximal oxygen you can consume during exercise. Assessed at 0-month (pre) and at 1-month (post)
Secondary Gut Microbiome Changes in Gut Microbiome. Participants' gut microbiome will be studied by analyzing stool samples DNA will be extracted, and the presence of selected gut bacterial populations will be examined qualitatively and quantitatively using specific primers and quantitative Real-Time PCR. Assessed at 0-month (pre) and at 1-month (post)
Secondary miRNA levels Changes in miRNA levels. miRNA levels that are associated with hypertrophy or cardiovascular function will be analyzed by blood sample collection at baseline and at one month. Assessed at 0-month (pre) and at 1-month (post)
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