Fatigue Clinical Trial
— IPACPOfficial title:
Integral Physiological Adaptations to Carbohydrate Periodization
Verified date | June 2023 |
Source | University of Thessaly |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this study is to examine the effect of long-term carbohydrate periodization protocols on sleep architecture, sleep quality, daytime sleepiness, physical performance, body composition, gut microbiome, and miRNA in healthy trained individuals.
Status | Completed |
Enrollment | 45 |
Est. completion date | May 31, 2023 |
Est. primary completion date | April 1, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 50 Years |
Eligibility | Inclusion Criteria: - Both sexes, Age between 18 and 50 yrs old, Regularly participating in sports activities. Exclusion Criteria: - Any kind of history of major diseases or medication, Excessive amounts of alcohol and caffeine consumption |
Country | Name | City | State |
---|---|---|---|
Cyprus | Department of Life and Health Sciences | Nicosia | |
Greece | Lifestlye Medicine Laboratory, TEFAA, University of Thessaly | Trikala | Thessaly |
Lead Sponsor | Collaborator |
---|---|
University of Thessaly | University of Cyprus, University of Nicosia |
Cyprus, Greece,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Sleep Efficiency | Changes sleep efficiency assessed by the gold-standard method of polysomnography. Sleep efficiency is the percentage of time spent asleep while in bed. It is calculated by dividing the amount of time spent asleep (in minutes) by the total amount of time in bed (in minutes). A normal sleep efficiency is considered to be 85% or higher. | Assessed at 0-month (pre) and at 1-month (post) | |
Primary | Quality of Sleep Score | Changes in Quality of Sleep will be assessed by the Pittsburgh Sleep Quality Index. The Pittsburgh Sleep Quality Index (PSQI) is a self-report questionnaire that assesses sleep quality over a 1-month time interval. The measure consists of 19 individual items, creating 7 components that produce one global score. The sleep component scores are summed to yield a total score ranging from 0 to 21 with the higher total score (referred to as the global score) indicating worse sleep quality. | Assessed at 0-month (pre) and at 1-month (post) | |
Primary | Daytime Sleepiness | Changes in Daytime sleepiness will be assessed by Epworth Sleepiness Scale (ESS). The Epworth Sleepiness Scale (ESS) measures the general level of daytime sleepiness. It is a subjective scale that asks the respondent to rate his or her propensity to doze or fall asleep during 8 common daily activities to determine the level of daytime sleepiness. The score varies between 0-24 with 0-5 Lower Normal Daytime Sleepiness, 6-10 Higher Normal Daytime Sleepiness, 11-12 Mild Excessive Daytime Sleepiness, 13-15 Moderate Excessive Daytime Sleepiness, 16-24 Severe Excessive Daytime Sleepiness. | Assessed at 0-month (pre) and at 1-month (post) | |
Secondary | Body Composition | Changes in Body composition. The changes in body composition will be assessed by the skinfold measurements and BIA | Assessed at 0-month (pre) and at 1-month (post) | |
Secondary | Exercise Performance | Changes in Exercise Performance will be assessed by a VO2max test. A VO2 max test is a maximal exercise test performed on a treadmill or bike while connected to a machine capable of analyzing your expired air. Your test provides data on how much oxygen you use as you exercise and determines the maximal oxygen you can consume during exercise. | Assessed at 0-month (pre) and at 1-month (post) | |
Secondary | Gut Microbiome | Changes in Gut Microbiome. Participants' gut microbiome will be studied by analyzing stool samples DNA will be extracted, and the presence of selected gut bacterial populations will be examined qualitatively and quantitatively using specific primers and quantitative Real-Time PCR. | Assessed at 0-month (pre) and at 1-month (post) | |
Secondary | miRNA levels | Changes in miRNA levels. miRNA levels that are associated with hypertrophy or cardiovascular function will be analyzed by blood sample collection at baseline and at one month. | Assessed at 0-month (pre) and at 1-month (post) |
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