Fatigue Clinical Trial
Official title:
Prevalence of Obstructive Sleep Apnea Syndrome in Sarcoidosis and Impact of CPAP Treatment on Associated Fatigue Status
Sarcoidosis is a multisystemic granulomatous disease that affects individuals worldwide
without known pathogenesis, and the role of comorbidities has not been fully assessed in the
scientific literature. An increased incidence of Obstructive Sleep Apnea Syndrome (OSAS) has
been described in Sarcoidosis although this association has not been explained yet and no
data is available about the effect of treatment with Continuous Positive Airway Pressure
(CPAP) in Sarcoidosis. Also, patients affected by Sarcoidosis usually experience a state of
physical and mental weariness called fatigue and reported in approximately 60-80% sarcoid
patients and thought to be a consequence of inflammatory mediators but the high prevalence of
OSAS could be a remarkable bias in clinical evaluation because fatigue is also strongly
associated with sleep disorders.
Thus, there is a real need for assessing not only the real prevalence of OSAS in Sarcoidosis
but also the effect of CPAP treatment on fatigue status experienced by sarcoidotic patients.
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