Fatigue Clinical Trial
Official title:
Development and Evaluation of a Cognitive-motor System for a Quantitative and Objective Measure of Fatigue in Functional MRI
The purpose of this study is to determine more objective, central and peripheral indices of
fatigue state by exploring the neural and behavioral correlates of the alert process while
keeping the idea to corroborate these results with those obtained during the performance of
physical exercises and neuropsychological tests "classics" of attention, motivation, and
functions evaluation. The interest of this study is to manipulate and compare the phasic and
tonic alert mechanism through the activation of an extrinsic motivational system during
fatigue. The investigators have chosen the alert since it is a basic cognitive process
defined as the ability to increase attentional resources with the expectation of a target
stimulus resulting in reduced response time. It can be phasic (extrinsic), favored by the
presence of a warning signal preceding the target (preparation time) or tonic (intrinsic)
occurring without warning signal (wakefulness). The evaluation of the alert is classically
realized by a simple reaction time task with the presence or not of warning signal
soliciting wether the tonic alert or the phasic alert.
The investigators suppose to revisit the healthy population with brain model alert issued in
2010 which highlighted the predominant role of the regions of the dorsolateral prefrontal
cortex, parietal, cingulate and thalamus (non-motor) in maintaining attention and temporal
preparation alert task.
The investigators identify also functional, motor and cognitive components of basal ganglia
of thalamus. Cognitive-motor paradigm and neurological dysfunctions observed in multiple
sclerosis population will help to identify and separate the cognitive role and motor brain
regions, particularly the thalamus and basal ganglia. New neurological hypotheses are
proposed
This project will be applied on healthy subjects, and the subject will be equipped with two
electrodes attached to the muscle of the left arm (flexor) to measure muscle activity. That
will be performed with a handgrip (the subject press on the handgrip).The subject will
receive two sessions. It will conduct a trial session in the laboratory to control his
ability to imagine the task (imagination run) and perform the driving task correctly.
Two saliva samples will be placed in tubes to be analysed to measure the concentration of
cortisol before and after functional MRI. Then, psychological and satisfaction
questionnaires will be completed by volunteers.
This protocol will then be adapted and transferred to multiple sclerosis population (in a
second study), for which fatigue is one of the symptoms most commonly reported.
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