Effect of Beta-Alanine on Heart Rate Response

Fatigue Clinical Trial

Official title:

The Effect of 28 Days of Beta-alanine Supplementation on the Physical Working Capacity at Heart Rate Threshold (PWCHRT)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01745016
• Other study ID #: 12-1787
• Status: Completed
• Phase: N/A
• First received: December 5, 2012
• Last updated: April 29, 2013
• Start date: January 2013
• Est. completion date: April 2013

Study information

• Verified date: April 2013
• Source: University of North Carolina, Chapel Hill
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

Beta-alanine, as a method to increase muscle carnosine, has been shown to enhance muscle buffering capacity and delay fatigue. Various fatigue tests have been utilized to examine the effectiveness of beta-alanine supplementation. The physical working capacity test has been used to show significant increases in physical working capacities following supplementation. The physical working capacity tests were originally developed by Moritani et al. 1981 and Devries et al. 1982 to measure the point of onset of muscular fatigue. It is hypothesized that beta-alanine will increase physical working capacity at heart rate threshold, thereby signifying a delay in fatigue.

Description:

An equal number of men and women will be recruited [Men, n=20 (10 placebo [PL]; 10 beta-alanine (Active)]; [Women,n=20 (10 PL; 10 Active)]. Men and women will be randomly assigned to respective groups to allow for equal numbers in supplement and placebo groups.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 35
• Est. completion date: April 2013
• Est. primary completion date: April 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Between the ages of 18-35 years old

• Be recreationally active (defined as accumulating 1-5 hours of moderate intensity

Exclusion Criteria

• Any health risks or indicators that would prevent them from participating in physical activity, as determined by a health history questionnaire

• Must not have taken performance enhancing supplements containing beta-alanine or creatine during the last 3 months

Study Design

Allocation: Randomized, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Investigator)

Related Conditions & MeSH terms

• Exercise
• Fatigue

Intervention

Dietary Supplement:
• Placebo

• Beta-alanine

Locations

Country	Name	City	State
United States	UNC Exercise and Sport Science	Chapel Hill	North Carolina

Sponsors (1)

Lead Sponsor	Collaborator
University of North Carolina, Chapel Hill

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Physical working capacity at heart rate threshold		0 to 4 weeks	No