The Qure Study: Q-fever Fatigue Syndrome - Response to Treatment — Qure  

Fatigue Syndrome, Chronic Clinical Trial

Official title: The Qure Study: Q-fever Fatigue Syndrome - Response to Treatment

Status Completed

Clinical Trial Summary

The objective of this study is to assess the efficacy of two treatment strategies for fatigue and disabilities in QFS: long term treatment with doxycycline or cognitive behavioral therapy (CBT).

Clinical Trial Description

Q fever fatigue syndrome (QFS) is one of the most frequent sequelae of Q fever, and constitutes a significant problem in the current outbreak of Q fever. QFS leads to substantial morbidity and has a high socio-economic burden, related to increased use of healthcare facilities and absence from work. It is envisaged that over 750 patients will become chronically fatigued due to Q fever in The Netherlands (20% of 4000 patients from 2007 until now). Although the outbreak appears to diminish, it is expected that Q fever will remain an endemic disease, and therefore this number will continue to grow. A vast medical consumption can be anticipated, stressing the need for an accessible and effective intervention and clear treatment guidelines.

The study will contribute to a better understanding of effective treatment of QFS, providing evidence-based guidelines for general practitioners and medical specialists. ;

Related Conditions & MeSH terms

• Coxiella Infection
• Fatigue
• Fatigue Syndrome, Chronic
• Fever
• Q Fever
• Syndrome

• NCT number: NCT01318356
• Study type: Interventional
• Source: Radboud University
• Status: Completed
• Phase: Phase 4
• Start date: April 2011
• Completion date: September 2015