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Clinical Trial Summary

Patients will undergo a split-mouth protocol which includes: a control group: in which the extraction of the lower third molar will be performed according to the standard protocols of the structure. A study group: in which ozone will be used in addition, in two formulations: gaseous, injected into the site of the pre- and post-surgery operation, and topical, in the form of a gel, applied at the end of the operation and for home use according to therapeutic scheme prescribed at the time of discharge. Primary objective: To evaluate whether the use of ozone in patients undergoing extraction of impacted third molars reduces post-operative pain 7 days after surgery. Secondary objectives: - Evaluate the functional limitation in opening the mouth (trismus) 7 days after surgery. - Evaluate if there is a reduced intake of analgesic drugs in the 7 days following the operation. - Evaluate the perceived quality of life in the 7 days following the intervention.


Clinical Trial Description

Patients will undergo a split-mouth protocol which includes: a control group: in which the extraction of the lower third molar will be performed according to the standard protocols of the structure. A study group: in which ozone will be used in addition, in two formulations: gaseous, injected into the site of the pre- and post-surgery operation, and topical, in the form of a gel, applied at the end of the operation and for home use according to therapeutic scheme prescribed at the time of discharge. Primary objective: To evaluate whether the use of ozone in patients undergoing extraction of impacted third molars reduces post-operative pain 7 days after surgery. Secondary objectives: - Evaluate the functional limitation in opening the mouth (trismus) 7 days after surgery. - Evaluate if there is a reduced intake of analgesic drugs in the 7 days following the operation. - Evaluate the perceived quality of life in the 7 days following the intervention. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05949476
Study type Interventional
Source Azienda Ospedaliera Ordine Mauriziano di Torino
Contact Paolo Appendino, Dr.
Phone +390115082222
Email pappendino@mauriziano.it
Status Recruiting
Phase N/A
Start date July 19, 2022
Completion date July 19, 2023