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Event-Related Potentials clinical trials

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NCT ID: NCT05355142 Recruiting - Clinical trials for Treatment Resistant Depression

An Intervention Study of Anhedonia and Pain Empathy in Depression

Start date: April 1, 2022
Phase: N/A
Study type: Interventional

Brain Network Mechanism of Pain Empathy and Anhedonia in Patients With Depression by Group Problem Management Plus Intervention.

NCT ID: NCT04425278 Recruiting - Clinical trials for Major Depressive Disorder

tDCS Intervention on Motivational Anhedonia of Major Depressive Disorder

Start date: March 1, 2018
Phase: N/A
Study type: Interventional

Study of tDCS intervention on motivational anhedonia of Major Depressive Disorder

NCT ID: NCT03991572 Recruiting - Clinical trials for Treatment Resistant Depression

rTMS Intervention on Motivational Anhedonia of Treatment Resistant Depression and Brian Network Mechanism

rTMS
Start date: January 1, 2018
Phase: N/A
Study type: Interventional

Study of individualized accurate targeting rTMS intervention on motivational anhedonia of treatment resistant depression and brain network mechanism

NCT ID: NCT03576391 Completed - Mental Fatigue Clinical Trials

The Influence of Fatigue on Trunk Motor Control and Brain Activity

Start date: September 15, 2016
Phase: N/A
Study type: Interventional

This study aims at examining the influence of both physically and cognitively induced fatigue on trunk motor control on the one hand and brain activity related to movement preparation on the other hand, in healthy adult subjects. Furthermore, a comparison between the effects of both types of fatigue will be made. For this purpose a motor control task will be performed and compared before and after 3 specific interventions: i.e. a control intervention, a physical task and a cognitive task. Muscle and brain activity will be measured during each motor control task. It is hypothesised that motor control will not be altered after a control task, i.e. seated rest for 45 minutes. With regards to the physical fatigue condition, it is expected that trunk muscles will contract earlier after this task than before due to altered motor control. Cognitive fatigue is hypothesised to have similar underlying processes as physical fatigue, thus a similar earlier muscle contraction is also expected after cognitive fatigue. Lastly, as both types of fatigue are expected to induce a similar effect on motor control no significant differences between cognitive and physical fatigue are hypothesised. However, it is possible that the magnitude of this effect differs between types of fatigue, i.e. that 1 of both types has a bigger effect on motor control than the other. With regards to brain activity in preparation of a motor control task similar hypotheses are formulated: no effect of the control task on brain activity, earlier and possibly increased brain activity after both fatiguing tasks, and no differences between both types of fatigue besides a possible difference in magnitude of effect.

NCT ID: NCT03393078 Completed - Clinical trials for Obsessive-Compulsive Disorder

Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment for Obsessive Compulsive Disease

Start date: August 1, 2017
Phase: N/A
Study type: Interventional

To investigate the treatment effect of repetitive transcranial magnetic stimulation on Obsessive-compulsive disorder, and the underlying neural mechanism by functional MRI.

NCT ID: NCT00639548 Completed - Clinical trials for Electroencephalography

ERPS, BIS and Entropy for Neuromonitoring in ICU Patients

Start date: November 2004
Phase: N/A
Study type: Observational

Most critically ill patients receive sedative and analgesic drugs to attenuate discomfort and pain. The excessive use of sedatives and analgesics has undesirable effects for patients. Whereas undersedation is mostly easy to identify, oversedation with its associated problems is more difficult to recognize. Stopping sedation daily helps to avoid gross oversedation, but this is not always possible. Monitoring the depth of sedation is difficult and is currently based on clinical assessment and the use of clinical scoring systems. These scoring systems cannot be applied continuously, they are subjective and the level of consciousness can be altered when sedation is assessed. Several methods based on the electroencephalogram have been tested to avoid these problems, but the results have been disappointing so far, so the BIS Monitor an dthe Entropy monitor.We have previously shown that the time-locked cortical response to standard external stimuli (long-latency auditory evoked potentials or event-related potentials; ERPs) can discriminate between clinically relevant light to moderate and deep sedation levels in healthy volunteers, when sedation is induced with a combination of propofol or midazolam with remifentanil. We therefore hypothesized that ERPs may be used to monitor the depth of sedation in ICU patients as well. As the first step to test this hypothesis, we evaluated the use of ERPs to assess the level of sedation in patients undergoing elective major surgery and admitted to the ICU for short term postoperative mechanical ventilation.