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Estrogens clinical trials

View clinical trials related to Estrogens.

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NCT ID: NCT03528902 Completed - Hypertension Clinical Trials

Tamoxifen Therapy to Treat Pulmonary Arterial Hypertension

T3PAH
Start date: October 1, 2018
Phase: Phase 2
Study type: Interventional

The main purpose of this clinical trial is to examine the feasibility and effects of tamoxifen in subjects with pulmonary arterial hypertension (PAH). The study will evaluate how well the drug is tolerated, and its impact on functional condition and selected biomarkers. Changes in tricuspid annular plane systolic excursion (TAPSE) and other parameters determined by transthoracic echocardiography will be evaluated as well as changes in additional metrics such as six minute walk test distance, quality of life assessments, and hormone levels.

NCT ID: NCT02951949 Completed - Atherosclerosis Clinical Trials

Estrogen Exposure and Atherosclerosis in Postmenopausal Women

Start date: November 2014
Phase:
Study type: Observational

One hundred Spanish postmenopausal women accepted to be investigated for cardiovascular risk actors including clinical features, serum biochemical parameters, single nucleotide polymorphisms for estrogen receptor, and imaging parameters, carotid intima-media thickness (91 women) and coronary computed tomography (32 women). Multivariable analysis confirmed that both age and glucose level directly affected IMT. Estrogenic exposure, as measured by the allele associated with lower expression of the ER beta gene, was protective at the sinus and the wall. Findings at the coronary arteries, either moderate or high calcium index (CAC) and/or significant lumen stenosis were sporadic and did not allow for establishing association with any of the variables assessed.

NCT ID: NCT02434562 Completed - Hypogonadism Clinical Trials

Development and Validation of in Vitro Cell-based Bioassays for Nuclear Receptor Activation

Start date: April 2012
Phase: N/A
Study type: Observational

This is a prospective biobank set up to collect serum from patients with disorders associated with changes in androgens, estrogens or sex hormone-binding globulin (SHBG), before and/or after treatment.

NCT ID: NCT00264407 Completed - Progesterone Clinical Trials

Neural Changes in the Aging Auditory System

Start date: January 2001
Phase: Phase 1
Study type: Observational

The purpose of this study was to determine the effects of hormone replacement therapy (HRT) on hearing in post-menopausal women.