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A Study of Camrelizumab Combined With Chemotherapy as Neoadjuvant Therapy in Adcanced Esophageal Squamous Cell Carcinoma (ESCC)

Esophageal Squamous Cell Carcinoma Clinical Trial

Official title:
PD-1 Monoclonal Antibody Camrelizumab Combined With Albumin Paclitaxel and Platinum for Neoadjuvant Treatment of Adcanced Esophageal Squamous Cell Carcinoma (ESCC): A Single-center, Single-arm Phase II Clinical Study

Clinical Trial Summary

To evaluate the efficacy and safety of camrelizumab combined with albumin paclitaxel and platinum chemotherapy in the preoperative treatment of locally advanced thoracic esophageal squamous cell carcinoma

Clinical Trial Description

Primary outcome: 1. Analysis of prognosis efficacy of patients: pathologic complete response (pCR) Secondary outcome: Overall survival(OS), Progressive-free survival(PFS), Disease control rate(DCR), Objective response rate(ORR), and the proportion of subjects who completed all treatments and radical resection (R0); Explorative outcome: To explore the efficacy of ultrasound gastroscopy, PET/CT, peripheral circulating blood tumor cell (CTC) detection and CTC-based immunofluorescence detection of PD-L1 antibody for the treatment of locally advanced ESCC with camrelizumab combined with albumin paclitaxel and platinum and potential biomarkers for predicting the efficacy of camrelizumab, including but not limited to immunohistochemical detection of PD-L1 expression in tumor specimens, T cell receptor (TCR) sequencing analysis in peripheral blood, and esophageal microbiome Analysis, etc.; patients' quality of life ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04767295
Study type Interventional
Source Hunan Cancer Hospital
Contact Wenxiang Wang
Phone +8613808454225
Email wangwenxiang@hnca.org.cn
Status Recruiting
Phase Phase 2
Start date March 1, 2021
Completion date March 1, 2023
View Details
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