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Z650 in Advanced Esophageal Squamous Cell Carcinoma With EGFR Over Expression or Gene Amplification

Esophageal Squamous Cell Carcinoma Clinical Trial

Official title:
A Phase Ib, Multi-center, Open-label Study of Z650 in Advanced Esophageal Squamous Cell Carcinoma (ECSS) With Epidermal Growth Factor Receptor (EGFR) Over Expression or Gene Amplification

Clinical Trial Summary

The purpose of this study is to evaluate the safety and efficacy of Z650 in Advanced Esophageal Squamous Cell Carcinoma patients With EGFR Over expression or Gene Amplification.

Clinical Trial Description

It is a multi-center , open-label, singer arm study to explore the safety and efficacy of Z650 in advanced ESCC patients who had experienced systematic chemotherapy. Approximately 45 subjects will be enrolled, each subjects will receive oral Z650, at dose of 350 mg/d, repeatedly until disease progression or unacceptable toxicity occurs, each cycle is defined as 28 days. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03888092
Study type Interventional
Source Sunshine Lake Pharma Co., Ltd.
Contact
Status Completed
Phase Phase 1/Phase 2
Start date August 18, 2017
Completion date December 13, 2022
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