POEM for Spastic Esophageal Disorders

Status Recruiting

Clinical Trial Summary

This study evaluates the efficacy and safety of the Per-Oral Endoscopic Myotomy (POEM) technique for lower esophageal sphincter myotomy in patients suffering from spastic esophageal disorders such as achalasia at a Canadian institution.

The investigators hypothesize that POEM is a safe and effective technique for the surgical management of such disorders at our institution.

Clinical Trial Description

Standard surgical care for spastic esophageal disorders such as achalasia includes a procedure called Heller myotomy.

The treatment in our study, called endoscopic myotomy (also known as peroral endoscopic myotomy - POEM) is different from standard surgery (Heller myotomy) because it is less invasive, is less likely to cause reflux, and usually requires shorter operative times with less loss of blood during the surgery. Although POEM has been adopted worldwide and has proven to be successful, the experience in Canada is very limited to date. ;

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02425033
Study type	Interventional
Source	University Health Network, Toronto
Contact	Eran Shlomovitz, MD
Phone	416-340-3287
Email	eran.shlomovitz@uhn.ca
Status	Recruiting
Phase	N/A
Start date	April 2015
Completion date	December 2018

View Details

See also
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Active, not recruiting	`NCT00188344` - A Randomized Comparison of Laparoscopic Myotomy and Pneumatic Dilatation for Achalasia	N/A
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Not yet recruiting	`NCT05010889` - Quality of Life After POEM for Achalasia
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Active, not recruiting	`NCT01750385` - Bacteremia and Procalcitonin Levels in Peroral Endoscopic Myotomy for Achalasia	N/A
Active, not recruiting	`NCT03404739` - Single- Versus Multiple-dose Antimicrobial Prophylaxis for The Prevention of Infectious Complications Associated With Peroral Endoscopic Myotomy(POEM) for Achalasia	Phase 2/Phase 3
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Recruiting	`NCT05899842` - Routine Versus Symptomatic Protein Pump Inhibitor Therapy for Prevention of Gastroesophageal Reflux After Per Oral Endoscopic Myotomy for Esophageal Achalasia	N/A
Completed	`NCT03702647` - Ropivacaine For Post-POEM Pain Control	N/A
Recruiting	`NCT01637311` - Peroral Endoscopic Remyotomy for Failed Heller Myotomy	N/A
Completed	`NCT00004416` - Randomized Study of Botulinum Toxin Type A for Achalasia	N/A