Esophageal Achalasia Clinical Trial
Official title:
Per Oral Endoscopic Myotomy (POEM) and Prolonged Dilatation (PRD) as Additional Endoscopic Treatment Options for Achalasia and Other Esophageal Motility Disorders
Achalasia is an esophageal motility disorder, which leads to clinical symptoms such as
dysphagia, regurgitation, chest pain and consecutive weight loss.
Although conventional treatment such as laparoscopic Heller myotomy (LHM) and balloon
dilatation (BD) can provide sufficient symptom relief in many patients, both interventions
have their individual drawbacks. Additionally, treatment after failed LHM or BD can be
challenging and in few might even lead to esophagectomy.
Per oral endoscopic myotomy (POEM) and prolonged dilatation (PRD) are two novel
endoscopically performed therapeutic options for achalasia and other esophageal motility
disorders. Both not only appear to provide good results, when performed as initial treatment
but also might be an excellent option after e.g failed LHM.
The purpose of this study is to evaluate the long-term efficacy of four different treatment
options, such as POEM, PRD with stent-fixation, PD and conventional LHM for achalasia in an
individualized treatment setting.
n/a
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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