Clinical Trials Logo

Clinical Trial Summary

Achalasia is the most common motility disorder of esophagus, characterized by disorders of the lower esophageal sphincter (LES). Normal peristalsis of the esophagus is eliminated and replaced by synchronous or ineffective contraction. Based on high-resolution manometry (HRM), the participants with achalasia were categorized into 3 subtypes, type I: achalasia with minimum esophageal pressurization, type II: achalasia with esophageal compression and type III: achalasia with spasm. Previous studies have found that the pathological features of the esophageal muscular layers in participants with achalasia are degeneration of nerve plexus, reduction of interstitial cells of Cajal (ICCs) and infiltration of different inflammatory cells. Different subtypes of achalasia have different pathological characteristics and esophageal motility. Now, per-oral endoscopic myotomy (POEM) is a main therapy for participants with achalasia. Most studies have focused on the relationship between pathological features and motility characteristics of achalasia, but there are few studies on the relationship between pathological features and therapeutic effect of POEM. This study will prospectively collect data of participants undergoing POEM for achalasia in Beijing Friendship Hospital, including demographic data, drug and surgical treatment data during hospitalization. All participants are required to obtain esophageal muscle biopsy for pathological examination during POEM. The participants will be followed up until 12 months for improvement in clinical symptoms.


Clinical Trial Description

Achalasia is the most common motility disorder of esophagus, characterized by disorders of the lower esophageal sphincter (LES). Normal peristalsis of the esophagus is eliminated and replaced by synchronous or ineffective contraction. Based on high-resolution manometry (HRM), the participants with achalasia were categorized into 3 subtypes, type I: achalasia with minimum esophageal pressurization, type II: achalasia with esophageal compression and type III: achalasia with spasm. Previous studies have found that the pathological features of the esophageal muscular layers in participants with achalasia are degeneration of nerve plexus, reduction of interstitial cells of Cajal (ICCs) and infiltration of different inflammatory cells. Different subtypes of achalasia have different clinical characteristics and esophageal motility. Studies have found that ganglion cells in type I participants are significantly reduced compared with type II participants, but the pattern is similar, which may indicate that type I achalasia represents the progression of type II achalasia. In addition, Achalasia is related to viral infection and autoimmune disease. Studies have shown that pathological biopsies of muscle in participants with achalasia show significantly increased rates of lymphocytes in tissues, as well as mast cells. Now, per-oral endoscopic myotomy (POEM) is a main therapy for participants with achalasia. Most studies have focused on the relationship between pathological features and motility characteristics of achalasia, but there are few studies on the relationship between pathological features and therapeutic effect of POEM. This study will prospectively collect data of participants undergoing POEM for achalasia in Beijing Friendship Hospital, including demographic data, drug and surgical treatment data during hospitalization. All participants are required to obtain esophageal muscle biopsy for pathological examination during POEM. The participants will be followed up until 12 months for improvement in clinical symptoms and gastroesophageal reflux after POEM. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05113173
Study type Observational
Source Beijing Friendship Hospital
Contact Fandong Meng
Phone +8613681061594
Email [email protected]
Status Recruiting
Phase
Start date May 11, 2021
Completion date April 16, 2023

See also
  Status Clinical Trial Phase
Active, not recruiting NCT03962179 - Feasibility and Efficacy of a Combination of a SEMS and Vacuum Wound Treatment (VACStent) N/A
Withdrawn NCT02663206 - Peroral Endoscopic Myotomy Versus Botulinum Toxin Injection in Spastic Esophageal Disorders N/A
Active, not recruiting NCT00188344 - A Randomized Comparison of Laparoscopic Myotomy and Pneumatic Dilatation for Achalasia N/A
Recruiting NCT04578769 - Assessment of Different Modified POEM for Achalasia N/A
Not yet recruiting NCT05010889 - Quality of Life After POEM for Achalasia
Recruiting NCT02572193 - To Assess the Feasibility of Same Day Discharge Following a POEM Procedure N/A
Recruiting NCT02606578 - Achalasia Patient Reported Outcomes
Active, not recruiting NCT01750385 - Bacteremia and Procalcitonin Levels in Peroral Endoscopic Myotomy for Achalasia N/A
Active, not recruiting NCT03404739 - Single- Versus Multiple-dose Antimicrobial Prophylaxis for The Prevention of Infectious Complications Associated With Peroral Endoscopic Myotomy(POEM) for Achalasia Phase 2/Phase 3
Recruiting NCT04112693 - Assessment of the Neuro-glio-epithelial Unit (NGEU) in Biopsies Taken During Peroral Endoscopic Myotomy (POEM) for Achalasia: a Feasibility and Safety Study. N/A
Completed NCT02999451 - Snare-assisted POEM for Treatment of Esophageal Achalasia N/A
Completed NCT00490750 - Laparoscopic Dor Versus Toupet Fundoplication for the Treatment of Idiopathic Esophageal Achalasia N/A
Recruiting NCT02518542 - Per Oral Endoscopic Myotomy (POEM) and Prolonged Dilatation (PRD) for Achalasia N/A
Recruiting NCT00260585 - Esophageal Cancer Risk Registry
Completed NCT03702647 - Ropivacaine For Post-POEM Pain Control N/A
Recruiting NCT01637311 - Peroral Endoscopic Remyotomy for Failed Heller Myotomy N/A
Completed NCT00004416 - Randomized Study of Botulinum Toxin Type A for Achalasia N/A
Not yet recruiting NCT03733756 - to Explore the Influence of Longitudinal Muscle on the Prognosis of Achalasia Patients After Peroral Endoscopic Myotomy (POEM) N/A
Recruiting NCT03012854 - Different Surgical Procedures of Peroral Endoscopic Myotomy(POEM) for Esophageal Achalasia N/A
Completed NCT03944863 - Impact of Antibiotic Prophylaxis in Per-oral Endoscopic Myotomy for Esophageal Motor Disorders