Fatigue Syndrome, Chronic Clinical Trial
Official title:
Chronic Fatigue Following Acute Epstein-Barr Virus Infection in Adolescents
Chronic fatigue syndrome (CFS) is characterized by unexplained, disabling and long lasting
fatigue, as well as pain, impaired memory, sleep difficulties and other symptoms.
Epstein-Barr virus (EBV) infection might precipitate CFS. In this study, 200 adolescents
undergoing acute EBV infection will be followed prospectively, and also compared with a
group of healthy controls. The aim is twofold:
- To identify factors that predispose to chronic fatigue among adolescents with acute EBV
infection
- To compare pathophysiological features of patients with acute EBV infection with a
group of healthy controls.
Possible risk factors for chronic fatigue 6 months after EBV-infection includes:
- Severity of the initial infection
- Immune responses characteristics
- Characteristics of the neuroendocrine stress response
- Cognitive functioning
- Emotional disturbances
- Genetics/ epigenetics of candidate genes
- Certain personality traits
- Critical life events
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