Epiretinal Membrane Clinical Trial
Official title:
Evaluation of Multifocal ERG and Visual Field Changes After Vitrectomy and ILM Peeling
To evulate changes in MfERG, VF and OCT after viterctomy associated with ILM peeling.
Macular epiretinal membrane (ERM) is a disorder of the vitreomacular interface characterized
by fibrocellular proliferation on the anterior surface of the internal limiting membrane (ILM)
of the macula. Pars plana vitrectomy with ERM removal and inner limiting membrane peeling is
the standard surgical treatment for an ERM. ILM peeling is performed to eliminate the
scaffold for myofibroblast proliferation and any microscopic ERM in order to prevent ERM
recurrence. ILM peeling is indicated for other pathologies other than ERM such as, diabetic
macular edema, and macular hole. ILM peeling is a traumatic procedure that may have many
effects on the underlying inner retinal layers that may lead to changes in retinal function.
Retinal edema, eccentric scotoma, dissociation of the nerve fiber layer, iatrogenic punctuate
chorioretinopathy, and subretinal, retinal, and vitreous hemorrhage are well described
secondary to the surgical trauma of peeling in addition to stain toxicity. Investigation of
these changes may assist in aiding the development of minimally traumatic techniques for ILM
removal .
Evaluation of functional changes may include visual field and Multifocal electroretinography
assessment. Visual field defect after vitrectomy a well known post operative complication
usually in eyes that underwent fluid air exchange, the cause of visual field defect remain
unclear.
Optical Coherence Tomography (OCT), imaging is done to evaluate inner retinal layers after
ILM peeling,High myopic eyes might develop more severe, "scattered" inner retinal defects
after ILM peeling.
Multifocal electroretinography (mfERG), has been used to assess visual function and the
electrophysiologic responses of multiple retinal locations of the macular area
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03332758 -
Inflammasomes in Cell Death in FTMH, ERM, and RRD
|
||
| Active, not recruiting |
NCT04130841 -
Effects of Internal Limiting Membrane Peeling on Visual Function in Epiretinal Membrane Surgery
|
N/A | |
| Recruiting |
NCT03713268 -
Intraoperative OCT Guidance of Intraocular Surgery II
|
||
| Terminated |
NCT01532765 -
Randomized Trial Comparing Epiretinal Membrane Surgery With and Without Internal Limiting Membrane Removal
|
N/A | |
| Completed |
NCT01474655 -
Retinal Layers and Visual Rehabilitation After Epiretinal Membrane Removal
|
N/A | |
| Active, not recruiting |
NCT04120311 -
Episcleral Dexamethasone for Treatment of Macular Edema and Inflammatory Disorders of the Posterior Pole
|
Phase 1 | |
| Completed |
NCT04445142 -
Fovea ERM After Fovea-sparing ILM Peeling
|
||
| Recruiting |
NCT01701518 -
A Pilot Study of the Effectiveness of Intra-operative Ozurdex® in Vitrectomy Surgery for Epiretinal Membranes
|
N/A | |
| Completed |
NCT01627977 -
Association of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy
|
Phase 3 | |
| Completed |
NCT00408720 -
Comparison of a Spectral OCT/SLO With the Stratus OCT for Imaging Various Retinal Pathologies
|
N/A | |
| Completed |
NCT01771939 -
Phacoemulsification and 25 Gauge (25G) Vitrectomy Versus Phacoemulsification Only in Idiopathic Epiretinal Membranes
|
N/A | |
| Completed |
NCT05171621 -
Measuring Subjective Quality of Vision and Metamorphopsia Before and After Epiretinal Membrane and Macular Hole Surgery
|
||
| Active, not recruiting |
NCT04306718 -
Cultivation of Hyalocytes From ILM and ERM Samples: a Pilot Study
|
N/A | |
| Recruiting |
NCT01985490 -
Change in Foveal Avascular Zone After Removal of Epiretinal Membrane and Internal Limiting Membrane
|
N/A | |
| Completed |
NCT01238393 -
Treatment of Epiretinal Membranes With Ranibizumab
|
N/A | |
| Terminated |
NCT00333060 -
Study of OT-551 Eye Drops to Prevent or Delay Progression of Nuclear Cataracts Following Vitreous Removal
|
Phase 2 | |
| Completed |
NCT05287269 -
Ocular Coherence Tomography During Cataract Assessment
|
||
| Recruiting |
NCT05138315 -
Quantification of Metamorphopsia in Patients With Epiretinal Membranes
|
N/A | |
| Recruiting |
NCT03661593 -
Aniseikonia in Epiretinal Membrane Patients
|
N/A | |
| Completed |
NCT03457584 -
Effect of Air-tamponade on Intraretinal Cystoid Changes After Membrane Peeling
|
N/A |