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Epilepsy clinical trials

View clinical trials related to Epilepsy.

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NCT ID: NCT06308185 Active, not recruiting - Epilepsy Clinical Trials

Neonatal Seizures: Semiology, Etiology, Therapy and Prognosis Correlations

Start date: June 1, 2021
Phase:
Study type: Observational

Epileptic seizures in newborns (often called "neonatal convulsions") represent the most frequent neurological problem in newborns (1-3/1000 newborns). The type of seizure and their etiology is very varied and therefore the therapeutic protocol also requires adaptations with a personalization of the therapeutic approach according to the characteristics of the case according to principles of precision medicine in particular for forms of neonatal epilepsy compared to epileptic seizures acute symptomatic. In recent years it has been highlighted that the clinical characterization and instrumental characterization, in particular electroencephalographic, of epileptic seizures represents an important biomarker that allows the choice of therapy to be oriented appropriately. In the literature there is a lack of single-center studies that relate the type of crisis according to the new ILAE 2017 classification (Fisher 2017) and its proposal for neonatal adaptation (Pressler 2021) with the etiology, type of therapy and outcome neurological after a few years. The primary aim of the study is to evaluate the correlation between the type of seizure determined according to the ILAE classification (clinical variables), the EEG findings of the epileptic seizures and the specific etiology of the epileptic seizures. The secondary aim is to evaluate the correlation between seizure type and etiology with effective therapy, length of hospitalization and neurobehavioral development outcome. The study design is a retrospective observational on the population of neonates managed at our center in the last decade.

NCT ID: NCT06198803 Active, not recruiting - Clinical trials for l Carnitine With Ketogenic Diet

The Effect of Carnitine Supplementation on Cardiac Function and Lipid Profile in Patients With Drug Resistant Epilepsy on Ketogenic Diet

Start date: January 3, 2022
Phase: Early Phase 1
Study type: Interventional

Primary aim: Demonstrating the effect of carnitine supplementation on lipid profile and cardiovascular functions in patients with DRE on KD. Secondary aim: To highlight the effect of carnitine supplementation on efficacy of KD in seizure control.

NCT ID: NCT06138847 Active, not recruiting - Clinical trials for Epilepsy; Syndrome, Seizures of Localized Onset

Does Levetiracetam and Carbamazepine Impact the Autonomic Activity of Children With Self-limiting Focal Epilepsy?

levcbz
Start date: January 1, 2023
Phase:
Study type: Observational

The goal of this cross-sectional study is to learn about autonomic cardiac profile changes in children with self-limiting focal epilepsy using levetiracetam and carbamazepine in children with self-limiting focal epilepsy syndrome. The main questions is it aims to answer are: 1. Are heart rate variability and autonomic tone different among healthy controls and children with epilepsy? 2. Does Levetiracetam and carbamazepine affect autonomic tone differently among children with self-limiting focal epilepsy?

NCT ID: NCT06040580 Active, not recruiting - Epilepsy Clinical Trials

Can we Use Resting-state fMRI and CSD Fiber Tractography for Presurgical Mapping?

Start date: October 8, 2018
Phase:
Study type: Observational

This prospective study aims to investigate and validate the use of resting-state functional MRI (rs-fMRI) and high angular resolution diffusion imaging (HARDI), specifically constrained spherical deconvolution (CSD) tractography, for functional and structural brain mapping prior to neurosurgery. The goal is to assess the feasibility of replacing task-based fMRI (tb-fMRI) and diffusion tensor imaging (DTI) with fiber tractography (FT) using the fiber assignment by continuous tracking (FACT) algorithm. The study focuses on mapping sensory-motor, language, visual, and higher cognitive functional and structural networks in patients with brain pathology suitable for surgical intervention. The objective is to improve neurosurgical planning, navigation, and risk assessment through the utilization of rs-fMRI and CSD tractography.

NCT ID: NCT06034353 Active, not recruiting - Epilepsy Clinical Trials

Impact of Pharmacist-led Cognitive Behavioral Intervention on Adherence and Quality of Life of Epileptic Patients

Start date: September 22, 2023
Phase: N/A
Study type: Interventional

The purpose of this interventional study is to assess the impact of pharmacist-led cognitive behavioral intervention in epileptic patients. The main questions are: 1. If pharmacist-led cognitive behavioral therapy can help in improving patient medication adherence? 2. How will the cognitive behavioral therapy impact the quality of life of the patients? Participants of this study will be provided basic or advanced level counselling and educational material as part of their routine pharmacy visit. Researchers will compare the two groups (Basic and advanced) to see which of the two groups are better in term of medication adherence and quality of life.

NCT ID: NCT05996900 Active, not recruiting - Clinical trials for Major Depressive Disorder

Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans

Start date: September 1, 2023
Phase: N/A
Study type: Interventional

Transcranial magnetic stimulation (TMS) is an effective treatment for depression, but clinical outcome is suboptimal, partially because investigators are missing biologically-grounded brain markers which show that TMS is modifying activity at the intended target in the brain. The goal of this proposal is to characterize the key markers of the brain's response to repeated doses of TMS with high resolution using invasive brain recordings in humans, and relate these brain markers to noninvasive recordings. These markers will improve the understanding of TMS and can be used to optimize and enhance clinical efficacy for depression and other psychiatric disorders.

NCT ID: NCT05898152 Active, not recruiting - Epilepsy Menstrual Clinical Trials

Interest of a Specific Care Pathway for the Management of Catamenial Epilepsy

EPICAT
Start date: May 3, 2023
Phase:
Study type: Observational

This is a study of patients with catamenial epilepsy. Catamenial epilepsies are defined as epileptic seizures during the menstrual cycle. Today, there are no recommendations and no care pathway for these patients. The aim of this study is to assess the number of patients reporting a link between the occurrence of their epileptic seizures and their menstrual cycle.

NCT ID: NCT05776745 Active, not recruiting - Epilepsy Clinical Trials

Study of Speech Function in Epileptic Patients Based on Stereoelectroencephalography Signal

Start date: March 20, 2022
Phase: N/A
Study type: Interventional

Based on stereoelectroencephalography model in the treatment of epilepsy patients, this study conducted language-related experimental studies without interfering with normal monitoring treatment. Meanwhile, voice data and intracranial electrophysiological data were collected for analysis. To study the mechanism related to the language function of patients, try to establish a model to decode the intracranial electrophysiological data related to language.

NCT ID: NCT05737784 Active, not recruiting - Epilepsy Clinical Trials

A Clinical Trial of PRAX-222 in Pediatric Participants With Early Onset SCN2A Developmental and Epileptic Encephalopathy

Start date: April 13, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

The goal of this trial is to learn about the effect of PRAX-222 in pediatric participants with early onset SCN2A developmental and epileptic encephalopathy (DEE), aged 2 to 18 years.

NCT ID: NCT05727943 Active, not recruiting - Clinical trials for Epilepsy Intractable

Add-on Clioquinol in Drug-resistant Childhood Epilepsy: an Exploratory Study

CLIOKID
Start date: March 1, 2022
Phase: Phase 2
Study type: Interventional

In this exploratory trial, the potential anti-seizure activity of clioquinol in a small cohort of adolescents with drug-resistant epilepsy will be examined. Subjects will be exposed to clioquinol add-on for a period of maximum 8 weeks (2 weeks low dose, 6 weeks higher dose). The main hypothesis of the study is that 30% of the included subjects will be responders and that the median seizure frequency reduction will be at least 30%.