Endovascular Thrombectomy Clinical Trial
Official title:
Medical Imaging Screening for Posterior-circulation Ischemic Strokeļ¼a Multicentre,Imaging-based,Prospective Cohort Study
Patients with ischemic stroke in the posterior circulation continue to have high rates of mortality and disability, even with aggressive treatment. We wanted to evaluate preoperative imaging to screen patients with a good prognosis from mechanical embolization. We assess the degree of ischemia by defining the pons-midbrain-medulla index (PMMI) and correlate the preoperative PMMI with the clinical prognosis of postoperative patients to verify the validity of PMMI in predicting the clinical prognosis of patients with embolization.
Status | Recruiting |
Enrollment | 1000 |
Est. completion date | December 31, 2029 |
Est. primary completion date | December 31, 2029 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility | Inclusion Criteria: 1. Patient admitted from Jun. 1st 2019 to Jan. 1st 2029; 2. Patients with acute ischemic stroke recently; 3. Symptoms persisted at admission, and MRI (including DWI) confirmed acute ischemic vertebrobasilar artery occlusion in the posterior circulation:(single right or left intracranial branch of vertebral artery occlusion ; single basilar occlusion ; both two vertebral arterys and basilar artery); Exclusion Criteria: 1.Patiens can not meet the MRI examination conditions(with absolute and relative contraindications). |
Country | Name | City | State |
---|---|---|---|
China | Beijing University Binhai Hospital | Tianjin | Tianjin |
China | The Sencond Hospital of Tianjin Medical University | Tianjin | Tianjin |
China | Tianjin Huanhu Hospital | Tianjin | Tianjin |
China | Tianjin Medical University General Hospital | Tianjin | Tianjin |
Lead Sponsor | Collaborator |
---|---|
Tianjin Huanhu Hospital |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | National Institutes of Health Stroke Scale (NIHSS) scores at 90 days | The NIHSS is composed of 11 items, each of which scores a specific ability between a 0 and 4. For each item, a score of 0 typically indicates normal function in that specific ability, while a higher score is indicative of some level of impairment. The individual scores from each item are summed in order to calculate a patient's total NIHSS score. The maximum possible score is 42, with the minimum score being a 0. | 90 days | |
Other | Occurrence of periprocedural complications | Periprocedural complications include any intracranial hemorrhage, cerebral edema, brain herniation and pneumonia. | 90 days | |
Other | pc-ASPECT (posterior circulation Alberta Stroke Program Early CT score) | pc-ASPECTS is a 10-point quantitative topographic CT scan score used in patients with posterior circulation stroke. | 0 days | |
Primary | Modified ranking scale (mRS) at 90 days | A 0-6 scale running from perfect health without symptoms to death. | 90 days | |
Secondary | Mortality within 90 days | mortality of any causes. | 90 days |
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