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Endothelium clinical trials

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NCT ID: NCT03682757 Completed - Blood Platelets Clinical Trials

Post-Injury Platelet Biology: Mechanisms and Outcomes

Start date: September 20, 2018
Phase:
Study type: Observational

Trauma-induced coagulopathy is a central cause of preventable deaths from hemorrhage after injury. The contribution and impact of altered post injury platelet biology on trauma-induced coagulopathy is not well understood despite the pivotal contribution of platelets to normal coagulation and endothelial integrity. The central hypothesis for this study is that severe injury and shock drive altered platelet activation, platelet aggregation, and platelet-endothelial interactions that are associated with increased rates of transfusion, organ failure, and mortality. This study will investigate these causal pathways, mechanisms, and associated outcomes in a prospective observational trauma cohort through collection of biospecimens and detailed clinical data.

NCT ID: NCT02023892 Not yet recruiting - Clinical trials for Hydroxymethylglutaryl-CoA Reductase Inhibitors

Single Dose of Atorvastatin and Circulating Endothelial Microparticles

Start date: June 2014
Phase: Phase 4
Study type: Interventional

Healthy subjects take single dose of 80mg atorvastatin, then measured their circulating endothelial microparticles and flow-mediated vasodilation in the brachial artery by ultrasound at different time points.

NCT ID: NCT01599728 Completed - Heart Failure Clinical Trials

Effect of Urocortins in Patients With Heart Failure

Start date: May 2012
Phase: N/A
Study type: Interventional

Despite modern advances in treatment, heart failure continues to carry a poor prognosis with high morbidity and mortality rates. Hence, there remains a major interest in the development of novel therapeutic agents for this debilitating condition. Urocortins have recently shot into limelight with their potential role in the pathophysiology and treatment of heart failure. Recent studies by the investigators group (REC no: 09/S1103/41) have confirmed that Urocortin 2 and 3 are potent arterial vasodilators, the effects of which are reproducible and well tolerated in healthy male volunteers. Previous studies using heart failure models in animals1-7, as well studies in heart failure patients (Urocortin 2), suggest that there is great scope for Urocortins as novel biomarkers and as potential therapeutic agents in heart failure. With this in mind, the investigators wish to study the local vasomotor effects of these peptides in greater detail in patients with heart failure.

NCT ID: NCT01312168 Active, not recruiting - Inflammation Clinical Trials

Endothelial Dysfunction, Monocyte Activation, and Vasculopathy in Patients With Obstructive Sleep Apnea (OSA) and Effect of 6-month CPAP Treatment

Start date: March 2011
Phase: N/A
Study type: Interventional

This purpose of this study is to 1. Determine the change in endothelial dependent vascular reactivity and vascular properties 2. Determine the changes in monocytes activation 3. Determine the change in pro-inflammatory status 4. Investigate the effect of six-month CPAP therapy on the above changes in patients with OSA