Endothelial Dysfunction Clinical Trial
Official title:
Assessment of Coronary Plaque Composition Using Near Infrared Spectroscopy During Inhibition of Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Activity
The investigators' hypothesis is that local activation of the endogenous Lipoprotein-associated phospholipase A2 (Lp-PLA2) plays an integral role in early atherosclerosis, and contributes to the mechanism of coronary endothelial dysfunction and to the structural and mechanical properties that characterize plaque vulnerability. Thus, this study will characterize prospectively the correlation between the functional and structural vascular wall properties, and the activity of the Lp-PLA2 pathway.
The present study will be a substudy of our National Institute of Health (NIH) funded and
Institutional Review Board (IRB) approved (08-008161) protocol "Lp-PLA2 and Coronary
Atherosclerosis in Humans" and (10-000044) "Lp-PLA2 and Coronary Atherosclerosis in Humans
Aim III" in which the investigators are examining the impact of long-term inhibition of
Lp-PLA2, with a specific novel inhibitor, on Lp-PLA2 activity and improvement in coronary
endothelial function.
The substudy will allow the investigators to also examine the additional endpoint of lipid
core content of atherosclerotic plaques and hence plaque vulnerability. Plaque lipid
composition will be measured using the LipiScan or LipiScan IVUS catheter (InfraReDx Near
Infrared Spectroscopy (NIRS) System with or without intravascular ultrasound (IVUS)
capability) at baseline and again at 6 month following Lp-PLA2 inhibition.
The study will provide insight into the role of the endogenous Lp-PLA2 in early coronary
atherosclerosis, a potential therapeutic target for early coronary atherosclerosis in humans.
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